Inventors:
Jane B. Lian - Westborough MA, US
Xinning Li - Framingham MA, US
David C. Ayers - Worcester MA, US
Jie Song - Shrewsbury MA, US
International Classification:
A61K 35/18, A61K 38/16, A61K 38/18, A61K 31/70, A61K 31/7088, A61K 9/10, A61K 38/19, A61P 19/02, A61P 19/08
US Classification:
424487, 514 12, 514 23, 514 44 R, 424486, 424 9373
Abstract:
The invention relates to composite materials that contain a polymer matrix and aggregates, and in some embodiments, methods of making, and methods of using these materials. Preferably, the aggregates are calcium phosphate aggregates. Preferably, the material is resistant to fracture. In further embodiments, the materials are used in surgical procedures of bone replacement. In further embodiments, the materials contain polyhedral silsesquioxanes and/or biodegradable segments. In further embodiments, the polymer matrix comprises biomolecules.