Inventors:
Xinmin Xu - Belle Mead NJ, US
David Erkoboni - Pennington NJ, US
David Lebo - Warminster PA, US
International Classification:
A61K031/19, A61K031/13, A61K031/16
Abstract:
A pharmaceutical composition comprising a pharmaceutically active agent and a salt of said pharmaceutically active agent with the proviso that said composition does not contain hydrolyzed cellulose, wherein said pharmaceutical active agent is a weak acid or weak base. The present invention is also directed to a new ibuprofen form having, when potassium is present in said form as a counter ion, an IR peak at 1706 cmshifted and broadened in absorbance relative to racemic ibuprofen free acid, the form's characteristic absorbance profile from 1000 to 650 cmand broadened in absorbance relative to racemic ibuprofen free acid, the form's characteristic absorbance profile from 1000 to 650 cmand D-spacings of 21.1, 7.1, and 3.4 by X-ray diffraction.