DR. DAVID APELIAN, MD, PHD
Medical Practice at Old Beach Glen Rd, Powerville, NJ
License number
New Jersey 210431
Category
Medical Practice
Type
Pediatrics
Address
Address
3 Old Beach Glen Rd, Powerville, NJ 07005
Phone
(973) 784-3372
Professional information
Immunotherapy For Chronic Hepatitis C Virus Infection
US Patent:
2011025, Oct 20, 2011
Filed:
Sep 18, 2009
Appl. No.:
13/119760
Inventors:
David Apelian - Boonton Township NJ, US
Richard C. Duke - Denver CO, US
Alex Franzusoff - Denver CO, US
Richard C. Duke - Denver CO, US
Alex Franzusoff - Denver CO, US
International Classification:
A61K 38/21, A61P 31/14, A61P 37/04, A61K 39/29, A61P 1/16
US Classification:
424 857, 4242281, 424 854, 4241921, 4241891
Abstract:
Disclosed are uses of immunotherapeutic compositions in combination with Standard of Care (SOC), or interferon therapy combined with anti-viral therapy, for the improved treatment of chronic hepatitis C virus (HCV) infection and related conditions, including liver function. The compositions, kits and uses of the invention, as compared to the use of SOC therapy alone: improves the rate of early response to therapy as measured by early virologic markers (e.g., RVR and EVR), enlarges the pool of patients who will have sustained responses to therapy over the long term, offers shortened courses of therapy for certain patients, enables “rescue” of patients who are non-responders or intolerant to SOC therapy, improves liver function and/or reduces liver damage in patients, and enables the personalization of HCV therapy for a patient, which can result in dose sparing, improved patient compliance, reduced side effects, and improved long term therapeutic outcomes.
Pharmacogenomic And Response-Guided Treatment Of Infectious Disease Using Yeast-Based Immunotherapy
US Patent:
2013012, May 16, 2013
Filed:
Mar 14, 2011
Appl. No.:
13/635254
Inventors:
David Apelian - Boonton Township NJ, US
Alex Franzusoff - Nahant MA, US
Alex Franzusoff - Nahant MA, US
Assignee:
GLOBEIMMUNE, INC. - Louisville CO
International Classification:
A61K 39/12, A61K 31/7056, A61K 38/21
US Classification:
424 857, 4242041, 424 854, 4241861
Abstract:
Disclosed are improved methods for treating an infectious disease with yeast-based immunotherapy, including viral disease, such as disease resulting from hepatitis virus infection, using a pharmacogenomic and response-guided approach based on IL28B genotype of the individual.
Compositions And Methods For Targeted Ablation Of Mutational Escape Of Targeted Therapies For Cancer
US Patent:
2010011, May 6, 2010
Filed:
Jan 17, 2008
Appl. No.:
12/531876
Inventors:
David Apelian - Boonton Township NJ, US
Alex Franzusoff - Denver CO, US
Timothy C. Rodell - Aspen CO, US
Alex Franzusoff - Denver CO, US
Timothy C. Rodell - Aspen CO, US
International Classification:
A61K 45/00, A61P 43/00
US Classification:
424 9321
Abstract:
Provided herein are compositions and methods for targeted ablation of mutational escape in the face of cancer therapeutic agents. Compositions comprising the yeast-based vehicles are used in combination with other cancer therapeutic agents.
Compositions And Methods For The Treatment Or Prevention Of Human Adenovirus-36 Infection
US Patent:
2014007, Mar 13, 2014
Filed:
Dec 19, 2011
Appl. No.:
13/994881
Inventors:
David Apelian - Boonton Township NJ, US
Thomas King - Denver CO, US
Claire Coeshott - Denver CO, US
Yingnian Lu - Denver CO, US
Thomas King - Denver CO, US
Claire Coeshott - Denver CO, US
Yingnian Lu - Denver CO, US
Assignee:
GLOBEIMMUNE, INC - Louisville CO
International Classification:
A61K 39/235
US Classification:
4241861, 530350
Abstract:
Disclosed are fusion proteins, recombinant nucleic acid molecules, and therapeutic compositions, including yeast-based immunotherapy compositions, for use in the diagnosis, prevention and treatment of adenovirus-36 (Ad-36) infection and sequela thereof.
Yeast-Based Therapeutic For Chronic Hepatitis B Infection
US Patent:
2014006, Mar 6, 2014
Filed:
Feb 9, 2012
Appl. No.:
13/984888
Inventors:
David Apelian - Boonton Township NJ, US
Thomas H. King - Denver CO, US
Zhimin Guo - Superior CO, US
Claire Coeshott - Denver CO, US
Thomas H. King - Denver CO, US
Zhimin Guo - Superior CO, US
Claire Coeshott - Denver CO, US
Assignee:
GLOBEIMMUNE, INC. - Louisville CO
International Classification:
A61K 39/29
US Classification:
4241891, 536 234, 530350, 4352542
Abstract:
Disclosed are yeast-based immunotherapeutic compositions, hepatitis B virus (HBV) antigens, and fusion proteins for the treatment and/or prevention of HBV infection and symptoms thereof, as well as methods of using the yeast-based immunotherapeutic compositions, HBV antigens, and fusion proteins for the prophylactic and/or therapeutic treatment of HBV and/or symptoms thereof.
Yeast-Brachyury Immunotherapeutic Compositions
US Patent:
2014000, Jan 2, 2014
Filed:
Mar 14, 2013
Appl. No.:
13/803719
Inventors:
The United States of America, as represented by the Secretary, Department of Health and Human Services - , US
David Apelian - Boonton Township NJ, US
Jeffrey Schlom - Potomac MD, US
David Apelian - Boonton Township NJ, US
Jeffrey Schlom - Potomac MD, US
Assignee:
The United States of America, as represented by the Secretary, Department of Health and Human Serv - Bethesda MD
GLOBEIMMUNE, INC. - Louisville CO
GLOBEIMMUNE, INC. - Louisville CO
International Classification:
A61K 39/00, A61K 36/064
US Classification:
4241851, 435 693
Abstract:
Disclosed are yeast-based immunotherapeutic compositions comprising Brachyury antigens, and methods for the prevention and/or treatment of cancers characterized by the expression or overexpression of Brachyury.