Inventors:
Caius G. Radu - Los Angeles CA, US
Johannes Czernin - Pacific Palisades CA, US
Jennifer M. Murphy - Los Angeles CA, US
David A. Nathanson - Los Angeles CA, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
International Classification:
C07D 417/12, C07D 417/14, G01N 33/50
US Classification:
424 111, 544317, 514274, 435184
Abstract:
The invention provides compounds that bind to deoxycytidine kinase (dCK) and compositions including pharmaceutically acceptable compositions containing the compounds. The compounds are useful in treating diseases and disorders where dCK activity is implicated such as cancer and immune disorders. The compounds also find use in clinical methodologies including positron emission tomography (PET) imaging.