Inventors:
Stephan R. Targan - Santa Monica CA, US
Jerome I. Rotter - Los Angeles CA, US
Kent D. Taylor - Ventura CA, US
David Ziring - Los Angeles CA, US
Jonathan Braun - Tarzana CA, US
Bo Wei - Rancho Palos Verdes CA, US
Assignee:
CEDARS-SINAI MEDICAL CENTER - Los Angeles CA
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA - Oakland CA
International Classification:
A61K 31/5377, C12Q 1/68, A61P 1/00
Abstract:
Diagnosis of Crohn's Disease by determining the presence or absence of variants at the CNR2 (cannabinoid) genetic locus and serological markers is disclosed Methods of diagnosing a Crohn's Disease sub-type by determining the presence or absence of one or more risk variants at the CNR2 5 locus and the presence or absence of ASCA, OmpC, 12 and/or anti-Cbir1 antibodies are included