Inventors:
Li Li - Centennial CO, US
Karen R. Jonscher - Centennial CO, US
David Norris - Greenwood Village CO, US
International Classification:
A61K 31/7088, A61P 19/02, A61P 35/00, A61P 17/06, A61P 3/10, A61P 11/06, A61P 31/18, A61P 31/12
Abstract:
The invention provides cytokine modulators and methods for using the same to modulate cytokine production in monocyte lineage-derived cells. In particular, cytokine modulators of the invention selectively bind to a T-cell cytokine-inducing surface molecule (TCISM)-ligand of T lymphocytes or the corresponding TCISM-receptor of monocyte lineage-derived cells, thereby modulating cytokine production in monocyte lineage-derived cells.