DR. DAVID ALAN BENARON, MD
Medical Practice at Siesta Ct, Menlo Park, CA
License number
California G68564
Category
Medical Practice
Type
Specialist
Address
Address
25 Siesta Ct, Menlo Park, CA 94028
Phone
(650) 854-2312
Professional information
Systems And Methods For The Detection And Analysis Of In Vivo Circulating Cells, Entities, And Nanobots
US Patent:
2008024, Oct 2, 2008
Filed:
Mar 27, 2007
Appl. No.:
11/729395
Inventors:
David A. Benaron - Portola Valley CA, US
Illian H. Parachikov - Belmont CA, US
Illian H. Parachikov - Belmont CA, US
International Classification:
A61B 5/145
US Classification:
424 91, 600368, 356 39
Abstract:
An improved circulating cell counter for generating light, and for delivering this light to a site in vivo for determining the presence, absence, concentration or count of a target cell, in which a light source such as a laser diode () and integrated optics () produce a beam transmitted to an in vivo target region (), such as a capillary bed with flowing cells in a living tissue. Based upon the movement of cells in and out of this region, a circulating cell count () is generated, allowing determination of the presence, absence, concentration or count of the target cell. Use with optical, magnetic, or nanobot contrast agents, and methods of use are also described.
Detecting, Localizing, And Targeting Internal Sites In Vivo Using Optical Contrast Agents
US Patent:
6246901, Jun 12, 2001
Filed:
Oct 16, 2000
Appl. No.:
9/690195
Inventors:
David A. Benaron - Portola Valley CA
International Classification:
A61B 600, A61B 505
US Classification:
600431
Abstract:
A system for detecting, localizing and targeting a medical instrument toward a target tissue within the body using an optical contrast agent in which a light source (102) is optically coupled to the tissue to be diagnosed (135), a light detector (174) is optically coupled to the tissue to detect a portion of the light which passes through the tissue, and either one or both of the light source and light detector are coupled to a medical instrument (130) used in a medical procedure. A contrast locator engine (184) receives a signal from the detector and provides an target tissue output signal (195) based upon the localization and distribution of the contrast agent, allowing the target tissue to be detected, located, or imaged, and for the medical instrument to positioned or targeted relative to the target tissue, and for allowing the accuracy of placement or the progress of a procedure to be assessed in real time. A method for the system is also described.
Metabolism- Or Biochemical-Based Anti-Spoofing Biometrics Devices, Systems, And Methods
US Patent:
2008022, Sep 18, 2008
Filed:
Mar 14, 2008
Appl. No.:
12/049122
Inventors:
David A. Benaron - Portola Valley CA, US
Illian H. Parachikov - Belmont CA, US
Michael Fierro - Los Gatos CA, US
Illian H. Parachikov - Belmont CA, US
Michael Fierro - Los Gatos CA, US
International Classification:
G06K 9/00
US Classification:
382115
Abstract:
A biometric device for detecting biological tissue based upon ratiometric measurements of metabolic and/or biochemical intermediates is provided in which a radiation source () is electromagnetically coupled to a target region (). A radiation sensor () receives emission signals () from the target region as a result of emitted radiation () interacting with the target region. A CPU () receives a signal from the sensor, and provides a biometric output signal based upon the presence of live, healthy tissue versus sham or dead tissue. Optionally, a conventional, non-metabolism, non-biochemical-based biometric sensor can be incorporated into the present invention, and the biometric output signal is then a result of both the metabolism- and/or biochemical based and non-metabolism non-biochemical-based biometric determinations. A method of performing this biometric analysis is also described.
Quantum Dot Led Device And Method
US Patent:
2011022, Sep 15, 2011
Filed:
Jan 28, 2011
Appl. No.:
13/016846
Inventors:
David A. Benaron - Portola Valley CA, US
IIlian H. Parachikov - Belmont CA, US
Michael R. Fierro - Los Gatos CA, US
IIlian H. Parachikov - Belmont CA, US
Michael R. Fierro - Los Gatos CA, US
Assignee:
SPECTROS CORPORATION - Portola Valley CA
International Classification:
H01L 33/50, B82Y 99/00
US Classification:
257 98, 438 29, 977774, 977950, 257E33067
Abstract:
An improved solid-state light source () for producing illuminating light () generated by interaction of light from an LED source () with a quantum dot, in one embodiment located in a well (). A solid-state illuminator with integrated quantum dots advantageously allows for an efficient broadband or narrow band LED to be produced in a variety of specified colors and color temperatures, and allows for a more compact, less heat producing, and more energy efficient manufacturable illumination device, and further facilitates integration of the illuminator and detector into medical, industrial, and laboratory illuminators, microchips, or lab-on-chip devices or systems. Methods of use are also disclosed.
White Led For Illumination With Additional Light Source For Analysis
US Patent:
2011013, Jun 9, 2011
Filed:
Jan 28, 2011
Appl. No.:
13/016874
Inventors:
David A. Benaron - Portola Valley CA, US
Ilian H. Parachikov - Belmont CA, US
Michael R. Fierro - Los Gatos CA, US
Ilian H. Parachikov - Belmont CA, US
Michael R. Fierro - Los Gatos CA, US
Assignee:
SPECTROS CORPORATION - Portola Valley CA
International Classification:
G01J 1/42, G01J 5/00, B82Y 99/00
US Classification:
2503381, 250372, 250395, 977774
Abstract:
An improved combination light source () comprises a combination of a solid-state white LED source () to illuminate a target with continuous, broadband illuminating light (), and a second, additional light source, as an integrated system. While the white LED provides illumination, the second light source provides for medical, industrial, or laboratory analysis. A combination solid-state and second illuminator integrated with one or more detectors advantageously allows for a more compact, less heat producing, and more energy efficient manufacturable device, and further facilitates integration of the illuminator and detector into a device or system. Methods of use are also disclosed.
Device And Method For Classification Of Tissue
US Patent:
5987346, Nov 16, 1999
Filed:
Dec 23, 1996
Appl. No.:
8/771952
Inventors:
David A. Benaron - Portola Valley CA
Boris Rubinsky - Albany CA
Boris Rubinsky - Albany CA
International Classification:
A61B 600
US Classification:
600407
Abstract:
A diagnostic monitor for classifying biological tissue in which a light emitter (102) is optically coupled to the tissue to be diagnosed (145) and a light detector (174) is optically coupled to the tissue to detect a portion of the light which passes through the tissue. The tissue classifier (184) receives a signal from the detector and provides an optical classification output signal (195), wherein the tissue is classified by type or state, either for detection, localization, or imaging. A method of classifying tissue is also described.
Non-Invasive Localization Of A Light-Emitting Conjugate In A Mammal
US Patent:
6939533, Sep 6, 2005
Filed:
Jul 24, 2002
Appl. No.:
10/205218
Inventors:
Pamela R. Contag - San Jose CA, US
Christopher H. Contag - San Jose CA, US
David A. Benaron - Portola Valley CA, US
Christopher H. Contag - San Jose CA, US
David A. Benaron - Portola Valley CA, US
Assignee:
Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
A61B010/00
US Classification:
424 96, 424 91, 424 961, 424 931, 424 932, 4353201, 435325, 435 79, 435368, 436800
Abstract:
Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen.
Biodetectors Targeted To Specific Ligands
US Patent:
2002008, Jul 4, 2002
Filed:
Oct 30, 1998
Appl. No.:
09/183566
Inventors:
PAMELA R. CONTAG - SAN JOSE CA, US
CHRISTOPHER H. CONTAG - SAN JOSE CA, US
DAVID A. BENARON - PORTOLA VALLEY CA, US
CHRISTOPHER H. CONTAG - SAN JOSE CA, US
DAVID A. BENARON - PORTOLA VALLEY CA, US
International Classification:
C12Q001/00, C12N005/00, C12N005/02
US Classification:
435/400000
Abstract:
The present invention relates to biodetectors for detecting and quantifying molecules in liquid, gas, or matrices. More specifically, the present invention relates to biodetectors comprising a molecular switching mechanism to express a reporter gene upon interaction with target substances. The invention further relates to methods using such biodetectors for detecting and quantifying selected substances with high specificity and high sensitivity.
Implantable Tissue Ischemia Sensor
US Patent:
2010031, Dec 9, 2010
Filed:
Aug 17, 2010
Appl. No.:
12/858396
Inventors:
David A. Benaron - Portola Valley CA, US
Ilian H. Parachikov - Belmont CA, US
Michael R. Fierro - Los Gatos CA, US
Ilian H. Parachikov - Belmont CA, US
Michael R. Fierro - Los Gatos CA, US
Assignee:
Spectros Corporation - Portola Valley CA
International Classification:
A61B 5/1455
US Classification:
600323
Abstract:
An implantable ischemia detection system in which a white LED () produces a continuous, visible, broadband light illuminating a target site (). Light backscattered by the target is collected by a sensor (), allowing for an index of ischemia to be determined, and subsequently transmitted by a sending unit (). Power is provided by an internal power source (). The entire implantable device is encapsulated by a biocompatible shell () to add long-term safety with regard to implantation.
Non-Invasive Localization Of A Light-Emitting Conjugate In A Mammal
US Patent:
6923951, Aug 2, 2005
Filed:
Dec 16, 2002
Appl. No.:
10/319542
Inventors:
Pamela R. Contag - San Jose CA, US
Christopher H. Contag - San Jose CA, US
David A. Benaron - Portola Valley CA, US
Christopher H. Contag - San Jose CA, US
David A. Benaron - Portola Valley CA, US
Assignee:
Board of Trustees of the Leland Stanford University - Palo Alto CA
International Classification:
A61K049/00
US Classification:
424 91, 424 96, 424 961, 424 931, 424 932, 4353201, 435325, 435 79, 435968, 436800
Abstract:
Methods and compositions for detecting and localizing light originating from a mammal are disclosed. Also disclosed are methods for targeting light emission to selected regions, as well as for tracking entities within the mammal. In addition, animal models for disease states are disclosed, as are methods for localizing and tracking the progression of disease or a pathogen within the animal, and for screening putative therapeutic compounds effective to inhibit the disease or pathogen.