Inventors:
Marc G. Caron - Hillsborough NC, US
Xiaodong Zhang - Durham NC, US
Martin Beaulieu - Durham NC, US
Raul R. Gainetdinov - Chapel Hill NC, US
Tatiana D. Sotnikova - Chapel Hill NC, US
Ranga R. Krishnan - Chapel Hill NC, US
David A. Schwartz - Hillsborough NC, US
Redford B. Williams - Hillsborough NC, US
Lauranell Burch - Durham NC, US
International Classification:
A61K 31/55, C12Q 1/68, A61K 31/131, A61K 31/135, A61K 31/343, A61K 31/4525, A61P 25/24
US Classification:
514217, 435 6, 514654, 514647, 514462, 514321
Abstract:
A method of screening a subject for a serotonergic neurotransmission dysregulation disorder comprises detecting the presence or absence of an Tph2 mutation in the subject; and then determining that the subject is at increased risk of a serotonergic neurotransmission dysregulation disorder due to the presence or absence of the Tph2 mutation.