DAVID A BERD
Medical Practice in Wyncote, PA
License number
Pennsylvania MD011257E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
Wyncote, PA 19095
Personal information
See more information about DAVID A BERD at radaris.comName
Address
Phone
125 Heacock Ln, Wyncote, PA 19095
Wyncote, PA
125 Heacock Ln, Wyncote, PA 19095
7742 Bradford St, Philadelphia, PA 19152
111 11Th St, Philadelphia, PA 19107
Professional information
Composition Comprising Tumor Cells And Extracts And Method Using Thereof
US Patent:
2003006, Apr 10, 2003
Filed:
Sep 27, 2002
Appl. No.:
10/260119
Inventors:
David Berd - Wyncote PA, US
Assignee:
Thomas Jefferson University
International Classification:
A61K039/00, A61K031/66
US Classification:
424/277100, 514/105000
Abstract:
The present invention is directed to compositions containing hapten-modified tumor cells and extracts and methods of treating cancer by administering a therapeutically effective amount of a composition containing a tumor cell or tumor cell extract to a subject in need of such treatment. The tumor cells and extracts of the invention and compositions thereof are capable of eliciting T lymphocytes that have a property of infiltrating a mammalian tumor, eliciting an inflammatory immune response to a mammalian tumor, eliciting a delayed-type hypersensitivity response to a mammalian tumor and/or stimulating T lymphocytes in vitro. The invention also relates to an effective vaccination schedule useful for inducing an antitumor response in a mammalian patient suffering from cancer by inducing at least one of the following: tumor necrosis, tumor regression, tumor inflammation, tumor infiltration by activated T lymphocytes, delayed-type hypersensitivity response, and prolongation of patient survival.
Mixed Haptenized Tumor Cells And Extracts And Methods Of Treating Or Screening For Cancer
US Patent:
2010022, Sep 2, 2010
Filed:
May 6, 2010
Appl. No.:
12/775281
Inventors:
David Berd - Wyncote PA, US
Assignee:
THOMAS JEFFERSON UNIVERSITY - Philadelphia PA
International Classification:
A61K 39/00, A61K 35/12, C12N 5/00
US Classification:
4242771, 424 937, 435325
Abstract:
This invention relates to compositions comprising multi-haptenized tumor cells and extracts thereof, methods for preparing the compositions, vaccines comprising such multi-haptenized tumor cells, and methods for treating cancer with such vaccines. In a specific embodiment, melanoma and ovarian adenocarcinoma cells are multi-haptenized, wherein the tumor cells are differentially haptenized either with a dinitrophenyl group coupled to s-amino groups, or with a sulfanilic acid group coupled to aromatic side chains of histidine and tyrosine. A method of SA-haptenization is also provided.
Method For Producing A Vaccine For The Treatment Of Cancer
US Patent:
2010009, Apr 22, 2010
Filed:
Dec 20, 2009
Appl. No.:
12/642827
Inventors:
DAVID BERD - WYNCOTE PA, US
Assignee:
AVAX TECHNOLOGIES, INC. - PHILADELPHIA PA
International Classification:
C12N 5/02
US Classification:
435374
Abstract:
The present invention discloses a method for producing a haptenized vaccine from a tissue biopsy. The method includes obtaining a tissue biopsy, isolating the cells, irradiating the cells, haptenizing the cells, and cryopreserving the cells. The present invention also discloses a method for treating cancer using the vaccines produced by the methods described herein.
Composition Comprising A Tumor Cell Extract And Method Of Using The Composition
US Patent:
2002000, Jan 10, 2002
Filed:
Oct 24, 1997
Appl. No.:
08/957691
Inventors:
DAVID BERD - WYNCOTE PA, US
LAWRENCE C. EISENLOHR - MERION STATION PA, US
EDMUND LATTIME - PRINCETON NJ, US
LAWRENCE C. EISENLOHR - MERION STATION PA, US
EDMUND LATTIME - PRINCETON NJ, US
International Classification:
A61K039/395, A61K039/00
US Classification:
424/277100
Abstract:
A novel composition comprising a therapeutically effective amount of a cancer cell extract and method of treating cancer are disclosed.
Mixed Haptenized Tumor Cells And Extracts And Methods Of Treating Or Screening For Cancer
US Patent:
2008004, Feb 21, 2008
Filed:
Dec 20, 2006
Appl. No.:
11/643626
Inventors:
David Berd - Wyncote PA, US
International Classification:
A61K 39/385, A61P 35/00, C12N 5/02
US Classification:
424277100, 435325000
Abstract:
This invention relates to compositions comprising multi-haptenized tumor cells and extracts thereof, methods for preparing the compositions, vaccines comprising such multi-haptenized tumor cells, and methods for treating cancer with such vaccines. In a specific embodiment, melanoma and ovarian adenocarcinoma cells are multi-haptenized, wherein the tumor cells are differentially haptenized either with a dinitrophenyl group coupled to ε-amino groups, or with a sulfanilic acid group coupled to aromatic side chains of histidine and tyrosine. A method of SA-haptenization is also provided.
Method For Producing A Vaccine For The Treatment Of Cancer
US Patent:
2006024, Oct 26, 2006
Filed:
Jan 13, 2006
Appl. No.:
11/331468
Inventors:
David Berd - Wyncote PA, US
International Classification:
A61K 39/00, A61K 31/66
US Classification:
424277100, 514109000
Abstract:
The present invention discloses a method for producing a haptenized vaccine from a tissue biopsy. The method includes obtaining a tissue biopsy, isolating the cells, irradiating the cells, haptenizing the cells, and cryopreserving the cells. The present invention also discloses a method for treating cancer using the vaccines produced by the methods described herein.
Cryopreservation Of Haptenized Tumor Cells
US Patent:
8435784, May 7, 2013
Filed:
Jun 13, 2007
Appl. No.:
11/762409
Inventors:
David Berd - Wyncote PA, US
Lorne F. Erdile - Loudonville NY, US
Margalit B. Mokyr - Skokie IL, US
Lorne F. Erdile - Loudonville NY, US
Margalit B. Mokyr - Skokie IL, US
International Classification:
A01N 1/00, A01N 1/02, C12N 5/00, C12N 5/02, C12N 5/07, C12N 5/16, G01N 33/574
US Classification:
435325, 435 13, 435 723, 435345
Abstract:
A method of preserving haptenized tumor cells is described. The method employs a freezing medium containing an effective amount of sucrose and human serum albumin in an isotonic buffered saline solution. Cryogenically preserving haptenized cells in such a medium has been found to maintain the integrity of the tumor cells during storage. The haptenized tumor cells also retain cell-associated antigens and haptens, and are as immunogenic, i. e. , capable of inducing immunotherapeutic response, as fresh vaccine in a mouse model of metastatic disease. In a specific embodiment, haptenized cells are exposed to a solution of 8% sucrose, 10% human serum albumin in Hank's buffered solution, and then frozen to −80° C. overnight and then stored in a liquid nitrogen freezer. Methods of storing haptenized tumor cells and compositions are also provided.
Cryopreservation Of Haptenized Tumor Cells
US Patent:
2005023, Oct 20, 2005
Filed:
Dec 9, 2004
Appl. No.:
11/009192
Inventors:
David Berd - Wyncote PA, US
Lorne Erdile - Loudonville NY, US
Margalit Mokyr - Skokie IL, US
Lorne Erdile - Loudonville NY, US
Margalit Mokyr - Skokie IL, US
International Classification:
A01N001/02
US Classification:
435002000
Abstract:
A method of preserving haptenized tumor cells is described. The method employs a freezing medium containing an effective amount of sucrose and human serum albumin in an isotonic buffered saline solution. Cryogenically preserving haptenized cells in such a medium has been found to maintain the integrity of the tumor cells during storage. The haptenized tumor cells also retain cell-associated antigens and haptens, and are as immunogenic, i.e., capable of inducing immunotherapeutic response, as fresh vaccine in a mouse model of metastatic disease. In a specific embodiment, haptenized cells are exposed to a solution of 8% sucrose, 10% human serum albumin in Hank's buffered solution, and then frozen to −80° C. overnight and then stored in a liquid nitrogen freezer. Methods of storing haptenized tumor cells and compositions are also provided.
Method Of Inducing An Immune Response Using Vaccinia Virus Recombinants Encoding Gm-Csf
US Patent:
6093700, Jul 25, 2000
Filed:
Feb 20, 1997
Appl. No.:
8/732505
Inventors:
Michael J. Mastrangelo - Jenkintown PA
Edmund C. Lattime - Princeton NJ
David Berd - Wyncote PA
Laurence C. Eisenlohr - Merion PA
Edmund C. Lattime - Princeton NJ
David Berd - Wyncote PA
Laurence C. Eisenlohr - Merion PA
Assignee:
Thomas Jefferson University - Philadelphia PA
International Classification:
A61K 4800, C12N 1500
US Classification:
514 44
Abstract:
A method of inducing expression of immune active cytokines in tumors in situ is provided wherein a vaccinia virus vector capable of inducing expression of a selected cytokine is generated and injected into a tumor so that cells of the tumor express the selected cytokine. A method of enhancing immunity in a host by administration of a vaccinia virus vector is also provided. Methods of treating cancer by administration of these vaccinia virus vectors are also provided.
Composition And Method Of Using Carcinoma Tumor Cells
US Patent:
7560103, Jul 14, 2009
Filed:
Dec 19, 2001
Appl. No.:
10/025195
Inventors:
David Berd - Wyncote PA, US
Assignee:
Thomas Jefferson University - Philadelphia PA
International Classification:
A61K 45/00
US Classification:
424 937, 4242771, 4241841, 4241931, 4242781, 424520
Abstract:
The present invention is directed to compositions and methods of treating cancer. The compositions of the present invention include a composition prepared from a tumor cell which is hapten modified and syngeneic to the type of tumor to be treated. The composition has the properties, when administered with an adjuvant to a human suffering from a malignant tumor of the same type as said tumor cell, of eliciting T lymphocytes that infiltrate the tumor of said human, of eliciting an inflammatory immune response against the tumor of said human, and of eliciting a delayed-type hypersensitivity response to the tumor of said human. The methods of the present invention are directed to treating cancer comprising administering a therapeutically effective amount of a composition comprising a tumor cell.