Inventors:
Laurence H. Hurley - Tucson AZ, US
Daruka Mahadevan - Tucson AZ, US
Haiyong Han - Chandler AZ, US
David J. Bearss - Cedar Hills UT, US
Hariprasad Vankayalapati - Draper UT, US
Sridevi Bashyam - Bangalore, IN
Ruben M. Munoz - Chandler AZ, US
Steven L. Warner - Sandy UT, US
Kimiko Della Croce - Tucson AZ, US
Daniel D. Von Hoff - Scottsdale AZ, US
Cory L. Grand - Dublin CA, US
James Welsh - Oro Valley AZ, US
Assignee:
Arizona Board of Regents on Behalf of The University of Arizona - Tucson AZ
Montigen Pharmaceuticals, Inc. - Salt Lake City UT
International Classification:
A61K 31/5377, C07D 487/04, A61K 31/519
US Classification:
5142328, 544250, 51425216, 544115, 514267
Abstract:
Protein kinase inhibitors are disclosed having utility in the treatment of protein kinase-mediated diseases and conditions, such as cancer. The compounds of this invention have the following structure:including steroisomers, prodrugs and pharmaceutically acceptable salts thereof, wherein A is a ring moiety selected from:and wherein R1, R2, R3, X, Z, L1, Cycl1, L2 and Cycl2 are as defined herein. Also disclosed are compositions containing a compound of this invention, as well as methods relating to the use thereof.