DARRELL JIRO YAMASHIRO
Medical Practice in Westwood, NJ
License number
Pennsylvania MD045073L
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
2
Westwood, NJ 07675
Pennsylvania
Pennsylvania
Personal information
See more information about DARRELL JIRO YAMASHIRO at radaris.comName
Address
Phone
49 Dean St, Westwood, NJ 07675
Westwood, NJ
49 Dean St, Westwood, NJ 07675
49 Dean St, Westwood, NJ 07675
Professional information
Systems, Methods, And Devices For Ultrasonic Assessment Of Cancer And Response To Therapy
US Patent:
2013025, Sep 26, 2013
Filed:
Aug 5, 2011
Appl. No.:
13/813236
Inventors:
Mark Andrew Borden - Boulder CO, US
Jessica Kandel - New York NY, US
Shashank Ramesh Sirsi - New York NY, US
Darrell Yamashiro - Westwood NJ, US
Jessica Kandel - New York NY, US
Shashank Ramesh Sirsi - New York NY, US
Darrell Yamashiro - Westwood NJ, US
Assignee:
The Trustees of Columbia University in the City of New York - New York NY
International Classification:
A61K 49/22
US Classification:
424 92
Abstract:
Microbubbles can be injected into the bloodstream of a patient, for example, a cancer patient undergoing a treatment specifically targeting a biological process in a tumor. The injected microbubbles can act as vascular contrast agents, which can be detected in vivo using high-frequency ultrasound imaging. The microbubbles can have a surface chemistry that allows them to bind to molecular targets in the tumor vasculature. After injection, the microbubbles can selectively adhere to endothelia expressing a target receptor. The selective adhesion can be used to quantify the tumor vasculature in vivo. By imaging the adhered microbubbles with ultrasound, an indication of how tumor vasculature is affected by a specific cancer treatment can be obtained. Such techniques can be used in a clinical setting for rapid determination of anti-cancer treatment efficacy for individual patients.
Method Of Tumor Regression With Vegf Inhibitors
US Patent:
2004026, Dec 30, 2004
Filed:
Jun 4, 2004
Appl. No.:
10/860958
Inventors:
Jessica Kandel - New York NY, US
Jocelyn Holash - Alameda CA, US
Darrell Yamashiro - Westwood NJ, US
Jianzhong Huang - New York NY, US
George Yancopoulos - Yorktown Heights NY, US
John Rudge - Mahopac NY, US
Jocelyn Holash - Alameda CA, US
Darrell Yamashiro - Westwood NJ, US
Jianzhong Huang - New York NY, US
George Yancopoulos - Yorktown Heights NY, US
John Rudge - Mahopac NY, US
International Classification:
A61K048/00, A61K038/17, A61K039/395
US Classification:
424/145100, 514/012000, 514/044000
Abstract:
Methods of regressing or inhibiting a tumor in a subject by administering an agent capable of blocking, inhibiting, or ameliorating vascular endothelial growth factor (VEGF)-mediated activity to a subject in need thereof such that the tumor is regressed or inhibited. The method of the invention results in a reduction of tumor size and inhibition of tumor metastases. This method is particularly useful for patients suffering from bulky, metastatic cancers.