Inventors:
Brian Robert Kovacevich - Snohomish WA, US
Leon F. Garcia-Martinez - Woodinville WA, US
Katie Olson - Kenmore WA, US
Benjamin H. Dutzar - Seattle WA, US
Jens J. Billgren - Seattle WA, US
John A. Latham - Seattle WA, US
Danielle M. Mitchell - Seattle WA, US
Patricia Dianne Mcneill - Federal Way WA, US
Nicole M. Janson - Edmonds WA, US
Maria-Cristina Loomis - Bothell WA, US
International Classification:
C07K 16/18, C12N 15/63, C12N 1/19, A61K 39/395, A61K 49/00, A61K 51/00, C12Q 1/68, C12N 5/10, C12N 1/15, C12N 1/21, A61P 25/06, A61P 3/00, A61P 35/00, A61P 25/00, A61P 29/00, A61P 19/08, A61P 1/16, A61P 13/12, A61P 13/00, A61P 3/10, A61P 37/00, A61P 9/00, A61P 19/02, A61P 11/00, A61P 11/06, A61P 25/36, A61P 15/00, A61P 17/00, A61P 17/06, A61P 25/08, A61P 25/28, A61P 17/04, A61P 1/00, A61P 37/08, A61P 31/00, C12N 15/13
US Classification:
424 111, 5303891, 5303873, 5303913, 5303917, 536 2353, 4353201, 43525423, 4241721, 424 91, 424 96, 5303911, 4241331, 435 61, 435332, 43525411, 43525233, 4241581
Abstract:
The present invention is directed to antibodies and fragments thereof having binding specificity for CGRP. Another embodiment of this invention relates to the antibodies described herein, and binding fragments thereof, comprising the sequences of the V, Vand CDR polypeptides described herein, and the polynucleotides encoding them. The invention also contemplates conjugates of anti-CGRP antibodies and binding fragments thereof conjugated to one or more functional or detectable moieties. The invention also contemplates methods of making said anti-CGRP antibodies and binding fragments thereof. Embodiments of the invention also pertain to the use of anti-CGRP antibodies, and binding fragments thereof, for the diagnosis, assessment and treatment of diseases and disorders associated with CGRP.