DR. DANIEL SIEV
Pharmacy at Westchester Ave, San Diego, CA

6506754, Jan 14, 2003

Apr 14, 2000

09/549453

Daniel Vanna Siev - San Diego CA
Gian Luca Araldi - San Diego CA
Jonathan Zhanqi Ho - Beijing, CN
John Eugene Reiner - San Diego CA
Joseph Edward Semple - San Diego CA

Corvas International, Inc. - San Diego CA

C07K 506

51425202, 544297, 544405, 544238, 514275, 51425506

The present invention provides compounds which have a pyrazinone or pyridinone ring at P3 and which feature a six member heterocyclic ring having two ring nitrogen atoms and the remainder of the ring atoms carbon atoms at P1. These compounds have biological activity as active and potent inhibitors of thrombin. Their pharmaceutically acceptable salts, pharmaceutical compositions thereof and methods of using these compounds and pharmaceutical compositions comprising these compounds as therapeutic agents for treatment of disease states in mammals which are characterized by abnormal thrombosis are also described.

6777431, Aug 17, 2004

Jul 13, 2001

09/905644

Daniel Vanna Siev - San Diego CA
Joseph Edward Semple - San Diego CA
Mallareddy Komandla - San Diego CA
John Eugene Reiner - San Diego CA
Scott Jeffrey Kemp - San Diego CA

Corvas International, Inc. - San Diego CA

C07D21363

514345, 546294, 544111, 5142315

The present invention provides compounds which have a pyrazinone or pyridinone ring at P3 and an optionally substituted heteroaryl group at P1. These compounds have biological activity as active and potent inhibitors of thrombin. Their pharmaceutically acceptable salts, pharmaceutical compositions thereof and methods of using these compounds and pharmaceutical compositions comprising these compounds as therapeutic agents for treatment of disease states in mammals which are characterized by abnormal thrombosis are also described.

6787612, Sep 7, 2004

Jul 24, 1998

09/122576

Daniel V. Siev - San Diego CA
J. Edward Semple - San Diego CA
Michael I. Weinhouse - Escondido CA

Dendreon Corporation - Seattle WA

C08F 332

525375, 5253299, 5253305, 5253336, 525376

This invention provides a method for producing a derivatized resin useful in the arts of solid-phase peptide synthesis, combinatorial chemistry, and peptide or protein purification and separation. Methods for synthesizing the derivatized resin, the prototypical example of which is hydrazyl-carbonyl-amino methylated polystyrene, are provided by this invention disclosure.

2004000, Jan 1, 2004

May 23, 2002

10/156214

Edwin Madison - San Diego CA, US
Joseph Semple - San Diego CA, US
George Vlasuk - Carlsbad CA, US
Scott Kemp - San Diego CA, US
Mallareddy Komandla - San Diego CA, US
Daniel Siev - San Diego CA, US

Corvas International, Inc.

A61K038/20, A61K038/19, A61K038/18, C07K014/52, C07K014/475, C07K014/415, A61K039/02

424/085100, 530/351000, 530/370000, 530/395000, 530/399000, 424/085200, 514/008000, 514/012000, 424/236100

Conjugates, compositions and methods for treatment, prevention, or amelioration of one or more symptoms of cell surface protease-related diseases, including MTSP-related, urokinase-type plasminogen activator (uPA) or endotheliase-related diseases, are provided. The conjugates for use in the compositions and methods are peptidic conjugates that contain therapeutic, including cytotoxic, agents.