Inventors:
Jay Wrobel - Lawrenceville NJ, US
John Rogers - Bryn Mawr PA, US
Daniel Green - Ambler PA, US
Wenling Kao - Paoli PA, US
James Jetter - Norristown PA, US
Assignee:
American Home Products Corporation - Madison NJ
International Classification:
A61K031/444, A61K031/4439, A61K031/4025, A61K031/185, A61K031/18, C 07D 4 3/02, C 07D 4 1/02
US Classification:
514/332000, 514/343000, 514/422000, 514/553000, 514/603000, 546/255000, 546/276400, 548/518000, 562/047000
Abstract:
This invention provides compounds of formula I having the structure
wherein Q is hydrogen or —SOR; X is a bond, O, S(O), —CH CH—, —CHCH—, —C≡C—, or —CHS(O)CH—; Ris OH, NH, Cto Calkoxy, Cto Cperfluoroalkoxy;
Rand Rare each, independently, hydrogen, OR, —S(O)R, —NHR, —N(R), or —CHSOCH; Rand Rare each, independently, hydrogen, —NO, —NH, —SOR, or —CHR; Ris hydrogen, Cto Calkyl, Cto Calkenyl, —CHCHZ, —CHCOR, —CHCH CHCOR
Yand Yare each, independently, N, or CH; Yand Yare each independently, O, S, or NR; Ris —OR, —NHR, —N(R), or —NHCHCHOR; Z is —OR, —OCHCHOR, —N(R), or
Ris hydrogen, or Cto Calkyl; Ris Cto Calkyl, Cto Calkenyl, OH, NHR, N(R), CHCOR, —CHCH CHCOR, or
Ris Cto Calkyl, Cto Calkenyl, phenyl, —CHCHOCH, or
Ris —OR, NHR, —N(R), or —NHCHCHOR; Ris hydrogen, or Cto Calkyl; Ris hydrogen, or Cto Calkyl; W is a bond, CH, CHCH, O, S(O), NCHO, NCOCH, or NR; m is 0-2; n is 0-2; q is 0-2, with the proviso that Rand Rare not both hydrogen; or pharmaceutically acceptable salt thereof, which are useful as contraceptive agents.