DANIEL M. MUSHER, M.D.
Osteopathic Medicine at Holcombe Blvd, Houston, TX

4146644, Mar 27, 1979

Jan 26, 1977

5/762629

Donald P. Griffith - Houston TX
Daniel M. Musher - Houston TX

A61K 31161

424320

A method for the treatment of urinary tract infections and a composition for use in such method, such method comprising administering to a patient suffering from a urinary tract infection an effective anti-bacterial dosage of a composition comprising in combination: A. a source of methenamine, e. g. methenamine; and B. a source of hydroxamate groups, e. g. , acetohydroxamic acid. The source of hydroxamate groups is administered in the amount effective to potentiate the anti-bacterial effect of the source of methenamine. The method is specifically applied to the treatment of urinary infections caused by urease producing bacteria, especially bacteria of the species Proteus. In addition, where colonization of the bacteria can be tolerated and where it is only necessary to eliminate the pathogenicity of the urease producing bacteria induced infection, effective treatment can be achieved by administration of only the source of hydroxamate groups, preferably acetohydroxamic acid. Also, by maintaining the urine at an acid pH in the presence of urease producing bacteria by administering a source of hydroxamate groups, struvite and apatite urinary stones normally associated with urease producing bacteria can be dissolved.

4024256, May 17, 1977

Sep 18, 1975

5/614684

Donald P. Griffith - Houston TX
Daniel M. Musher - Houston TX

A61K 3153

424249

A method for the treatment of urinary tract infections and a composition for use in such method, such method comprising administering to a patient suffering from a urinary tract infection an effective anti-bacterial dosage of a composition comprising in combination: A. a source of methenamine, e. g. methenamine; and B. a source of hydroxamate groups, e. g. , acetohydroxamic acid. The source of hydroxamate groups is administered in the amount effective to potentiate the anti-bacterial effect of the source of methenamine. The method is specifically applied to the treatment of urinary infections caused by urease producing bacteria, especially bacteria of the species proteus. In addition, where colonization of the bacteria can be tolerated and where it is only necessary to eliminate the pathogenicity of the urease producing bacteria induced infection, effective treatment can be achieved by administration of only the source of hydroxamate groups, preferably acetohydroxamic acid. Also, by maintaining the urine at an acid pH in the presence of urease producing bacteria by administering a source of hydroxamate groups, struvite and apatite urinary stones normally associated with urease producing bacteria can be dissolved.