Inventors:
Martin LeWinter - Williston VT, US
Harold Dauerman - Shelburne VT, US
Daniel Lustgarten - Burlington VT, US
Markus Meyer - Burlington VT, US
Assignee:
University of Vermont and State Agricultural College - Burlington VT
International Classification:
A61K 48/00, A61M 31/00
US Classification:
424009520, 424093200, 604500000
Abstract:
The invention relates to a method and device for recovering therapeutic and diagnostic agents from the venous outflow of a tissue or organ. A method for recovering an agent includes inserting a catheter into a vascular outflow of a tissue or organ, occluding the flow of blood/fluid through the vascular outflow, and withdrawing blood/fluid in the vascular outflow into the catheter to recover at least a portion of the agent administered to the vascular inflow of the organ or tissue. Also provided is a device to capture an agent administered to a vascular inflow, the device having a catheter having an expandable occlusion device to occlude a flow of fluid through the vascular outflow, a pump operably coupled to the catheter for withdrawing from the vascular outflow at least a portion of the agent administered to a vascular inflow of the organ or tissue, and an automated controller in signal communication with the catheter to control the expandable occlusion device and the pump to withdraw at least a portion of the agent from the vascular outflow.