Inventors:
John J. Rossi - Alta Loma CA, US
Daniela Castanotto - Altadena CA, US
Gerd Pfeifer - Bradbury CA, US
Stella Tommasi - South Pasadena CA, US
Kevin V. Morris - Sierra Madre CA, US
Daniel H. Kim - Duarte CA, US
International Classification:
C07H 21/04, C07H 21/02
Abstract:
The present invention relates to transcriptional gene silencing (TGS) in mammalian, including human, cells that is mediated by small interfering RNA (siRNA) molecules. The present invention also relates to a double stranded nucleic acid that directs methylation of histones associated with target genes that produce low copy promoter-specific RNA. It has been found that siRNAs can be used to direct methylation of histones in mammalian, including human, cells.