Methods For Treating Disorders Or Diseases Associated With Hyperlipidemia And Hypercholesterolemia While Minimizing Side Effects
US Patent:
8618135, Dec 31, 2013
Filed:
Mar 11, 2011
Appl. No.:
13/046118
Inventors:
Daniel J. Rader - Philadelphia PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
A61K 31/445, A61K 31/501, A61K 31/52
US Classification:
514321, 514325, 51425203, 51425503, 51426322
Abstract:
The present invention provides methods and compositions for treating hyperlipidemia and/or hypercholesterolemia comprising administering to the subject an effective amount of an MTP inhibitor to inhibit hyperlipidemia and/or hypercholesterolemia in said subject, wherein said administration comprises an escalating series of doses of the MTP inhibitor. In some embodiments the method comprises administering at least three step-wise, increasing dosages of the MTP inhibitor to the subject. In some embodiments, the method further comprises the administration of one or more other lipid modifying compounds.
Methods For Treating Disorders Or Diseases Associated With Hyperlipidemia And Hypercholesterolemia While Minimizing Side Effects
US Patent:
7932268, Apr 26, 2011
Filed:
Mar 7, 2005
Appl. No.:
10/591923
Inventors:
Daniel J. Rader - Philadelphia PA, US
Assignee:
The Trustees of the University of Pennsylvania - Philadelphia PA
International Classification:
A61K 31/445
US Classification:
514321, 514325
Abstract:
The present invention provides methods and compositions for treating hyperlipidemia and/or hypercholesterolemia comprising administering to the subject an effective amount of an MTP inhibitor to inhibit hyperlipidemia and/or hypercholesterolemia in said subject, wherein said administration comprises an escalating series of doses of the MTP inhibitor. In some embodiments the method comprises administering at least three step-wise, increasing dosages of the MTP inhibitor to the subject. In some embodiments, the method further comprises the administration of one or more other lipid modifying compounds.
Resistin As A Marker And Therapeutic Target For Cardiovascular Disease
US Patent:
2005024, Nov 3, 2005
Filed:
Feb 28, 2005
Appl. No.:
11/068806
Inventors:
Mitchell Lazar - Gladwyne PA, US Daniel Rader - Philadelphia PA, US Muredach Reilly - Philadelphia PA, US
International Classification:
G01N033/53
US Classification:
435007100
Abstract:
The risk or progression of cardiovascular disease and coronary artery disease is assessed in a mammalian subject by measuring the level or concentration of circulating serum resistin in a subject and comparing the measured level to resistin levels within a standardized or standard population. Methods of treating cardiovascular diseases and/or inflammatory disorders involve administering to a patient a composition that can reduce the circulating levels of resistin.
Dr. Daniel J Rader, Philadelphia PA - MD (Doctor of Medicine)
Specialties:
Internal Medicine
Address:
Penn Heart & Vascular Center 3400 Civic Center Blvd SUITE 2, Philadelphia 19104 (215) 615-4949 (Phone)
Certifications:
Internal Medicine, 1987
Awards:
Healthgrades Honor Roll
Languages:
English
Hospitals:
Penn Heart & Vascular Center 3400 Civic Center Blvd SUITE 2, Philadelphia 19104 Aria Health - Torresdale 10800 Knights Rd, Philadelphia 19114 Hospital of the University of Pennsylvania 3400 Spruce St, Philadelphia 19104
Education:
Medical School Medical College Of Pennsylvania Graduated: 1984 Yale New Haven Hospital Graduated: 1987
Daniel Rader, Philadelphia PA
Work:
University of Pennsylvania 3400 Civic Center Blvd, Philadelphia, PA 19104Clinical Health Care Associates NJ PC 3400 Spruce St, Philadelphia, PA 19175Clinical Health Care Associates NJ PC 39th And Market Sts, Philadelphia, PA 19104
Professor At Univ Of Pennsylvania
Position:
Professor of Medicine at Univ of Pennsylvania
Location:
Greater Philadelphia Area
Industry:
Hospital & Health Care
Work:
Univ of Pennsylvania - Greater Philadelphia Area since 1994
-
Professor of Medicine
Education:
Lehigh University
Daniel J Rader, Philadelphia PA
Specialties:
Internist
Address:
3400 Spruce St, Philadelphia, PA 19104 250 King Of Prussia Rd, Radnor, PA 19087 3400 Civic Center Blvd, Philadelphia, PA 19104
Education:
Medical College of Pennsylvania - Doctor of Medicine Yale New Haven Psychiatric Hospital - Residency - Internal Medicine
Board certifications:
American Board of Internal Medicine Certification in Internal Medicine
Resistin As A Marker And Therapeutic Target For Cardiovascular Disease
US Patent:
2011011, May 12, 2011
Filed:
Sep 2, 2010
Appl. No.:
12/874305
Inventors:
Mitchell A. Lazar - Gladwyne PA, US Daniel J. Rader - Philadelphia PA, US Muredach P. Reilly - Philadelphia PA, US
Assignee:
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA - Philadelphia PA
International Classification:
A61K 39/395, G01N 33/566, A61P 9/10
US Classification:
4241301, 436501
Abstract:
The risk or progression of cardiovascular disease and coronary artery disease is assessed in a mammalian subject by measuring the level or concentration of circulating serum resistin in a subject and comparing the measured level to resistin levels within a standardized or standard population. Methods of treating cardiovascular diseases and/or inflammatory disorders involve administering to a patient a composition that can reduce the circulating levels of resistin.
Daniel A Rader, Philadelphia PA
Specialties:
Dentist
Address:
7300 City Ave, Philadelphia, PA 19151
Method For In Vivo Measurement Of Reverse Cholesterol Transport
US Patent:
2012013, Jun 7, 2012
Filed:
Jan 13, 2012
Appl. No.:
13/350207
Inventors:
Daniel J. Rader - Philadelphia PA, US Jeffrey T. Billheimer - West Chester PA, US
International Classification:
H01J 49/26, G01T 1/00
US Classification:
250282, 250395
Abstract:
Methods and compositions for the in vivo measurement of reverse cholesterol transport are provided.