Daniel Edward Fox
Physical Therapy at Augusta Trl, Fort Collins, CO

8557587, Oct 15, 2013

Jan 6, 2010

12/683395

Daniel N. Fox - Fort Collins CO, US
George C. Malachowski - Melbourne, AU
Matthias J. G. Ottenberg - Holmen WI, US
Tidhar Sadeh - Fort Collins CO, US

XY, LLC - Navasota TX

G01N 31/00, G01N 33/00

436 10, 422 73, 702 21, 702 26, 702 46, 702128, 703 2

Disclosed is a self-tuning flow cytometer that uses a mathematical model to perform sort decisions that is based upon the biological response of the particular types of cells that are being sorted. In one embodiment, statistical calculations of the likelihood of an event belonging to a certain population are used to make the sort decisions. Automated self-tuning processes are used to optimize the operating parameters of the flow cytometer to achieve a selected purity with higher yield at optimal sorting speeds. The fully automated processes minimize user input and allows the user to select a desired purity while maximizing yield.

8619370, Dec 31, 2013

May 3, 2011

13/100261

Susan Hunter - Fort Collins CO, US
Daniel N. Fox - Fort Collins CO, US
Tidhar Sadeh - Fort Collins CO, US
Matthias J. G. Ottenberg - Holmen WI, US
Kevin P. Raley - Windsor CO, US

Bio-Rad Laboratories, Inc. - Hercules CA

G02B 27/14

359634, 359629, 359900

Disclosed is an optical combiner for combining multiple laser beams in a flow cytometer. A dichroic beam combiner is used to combine a second laser beam with a first laser beam so that the two beams are collinear. A beam size adjuster is utilized to adjust the size and convergence/divergence of the second laser beam so that both laser beams focus in a vertical direction at the same location on a stream in the flow cytometer. A cylindrical lens with a vertically oriented axis in the focusable beam shaping optics can also be adjusted to adjust the location of the focus point of the two beams in the horizontal direction. Alignment is maintained with the opto-mechanical adjustments made on one laser beam relative to the other laser beam path. Additional beams can also be added to the optical path.

2011030, Dec 15, 2011

Mar 10, 2011

13/044685

Christopher D. Lofstrom - Fort Collins CO, US
Daniel N. Fox - Fort Collins CO, US
Thomas L. Thrasher - Fort Collins CO, US
David C. Neckels - Berthoud CO, US

G01N 21/84, G01P 3/36, G01C 3/08

250573, 356 503, 356 28

A method is provided for generating measurement parameters for a particle sample in a particle analyzer. The method includes, interrogating the particle sample with a triggering interrogator and one or more secondary interrogators respectively positioned along a length of an interrogation area, generating respective pulses based upon the interrogation of a first particle from the particle sample, determining a primary pulse detection window based upon a triggering pulse, determining a search interval to find a secondary pulse based upon factors including the primary pulse detection window and a laser delay, adjusting the search interval for laser delay variation dynamically based on the interrogation of the first particle, identifying the secondary pulse in the adjusted search interval, and processing the secondary pulse to determine a peak value of the secondary pulse. Corresponding apparatus are also provided.

2013001, Jan 10, 2013

Sep 14, 2012

13/619845

Daniel N. Fox - Fort Collins CO, US
Thomas L. Thrasher - Fort Collins CO, US

G01F 1/60, G06F 15/00

702 46

Disclosed is an electronic processing system for a flow cytometer that uses a processing chip that processes data in a parallel architecture on a sample by sample basis and provides for high throughput of data. In addition, multi-gain linear amplifiers are used which are matched using feedback circuits to provide accurate data and high resolution data having high dynamic range.

8290751, Oct 16, 2012

Apr 7, 2011

13/082283

Daniel N. Fox - Fort Collins CO, US
Thomas L. Thrasher - Fort Collins CO, US

Beckman Coulter, Inc. - Brea CA

H03F 1/00, G06F 19/00

702189

Disclosed is an electronic processing system for a flow cytometer that uses a processing chip that processes data in a parallel architecture on a sample by sample basis and provides for high throughput of data. In addition, multi-gain linear amplifiers are used which are matched using feedback circuits to provide accurate data and high resolution data having high dynamic range.

7945428, May 17, 2011

Mar 21, 2008

12/053439

Daniel N. Fox - Fort Collins CO, US
Thomas L. Thrasher - Fort Collins CO, US

Beckman Coulter, Inc. - Brea CA

H03F 1/00, G06F 19/00

702189

Disclosed is an electronic processing system for a flow cytometer that uses a processing chip that processes data in a parallel architecture on a sample by sample basis and provides for high throughput of data. In addition, multi-gain linear amplifiers are used which are matched using feedback circuits to provide accurate data and high resolution data having high dynamic range.

7590500, Sep 15, 2009

Feb 28, 2005

10/587887

Theodore W. Jochum - Fort Collins CO, US
Daniel N. Fox - Fort Collins CO, US
Thomas L. Thrasher - Fort Collins CO, US
George Malachowski - Melbourne, AU

Beckman Coulter, Inc. - Fullerton CA

G01D 18/00

702 85, 702120, 341143, 356 28, 356 39

A flow cytometer capable of using electronics to analyze a large dynamic range while avoiding and/or correcting traditional limitations of acquisition electronics. The invention allows for measuring signal characteristics, which may include but are not limited to linear peak, integral, logarithmic peak, and pulse width. Other system parameters may also be generated by the invention to indicate timing or status information. Accurate and precise measurements may be performed by correcting for input errors if needed, and by transforming the input signal to produce a more easily measured form.