DANIEL E FREED
Nursing Home Administrators in Limerick, PA
License number
Pennsylvania NH006525
Category
Nursing Home Administration
Type
Nursing Home Administrator
Address
Address
Limerick, PA 19468
Personal information
See more information about DANIEL E FREED at radaris.comName
Address
Phone
427 Glendale Rd, Beaver Falls, PA 15010
4504 Wilfox Ave, Reading, PA 19605
615 12Th Street Ext, Ellwood City, PA 16117
6212 Glen Ct, Germansville, PA 18053
710 E Montgomery St, Allentown, PA 18103
Professional information
See more information about DANIEL E FREED at trustoria.com
Synthetic Hiv Gag Genes
Synthetic Hiv Gag Genes
US Patent:
6696291, Feb 24, 2004
Filed:
Oct 9, 2001
Appl. No.:
09/974702
Inventors:
John W. Shiver - Doylestown PA
Daniel C. Freed - Limerick PA
Mary Ellen Davies - Norristown PA
Margaret A. Liu - Rosemont PA
Helen C. Perry - Lansdale PA
Daniel C. Freed - Limerick PA
Mary Ellen Davies - Norristown PA
Margaret A. Liu - Rosemont PA
Helen C. Perry - Lansdale PA
Assignee:
Merck Co., Inc. - Rahway NJ
International Classification:
C12N 506
US Classification:
4353391, 435 5, 435 6, 435325, 536 231
Abstract:
Synthetic DNA molecules encoding HIV gag and modifications of HIV gag are provided. The codons of the synthetic molecules are codons preferred by the projected host cell. The synthetic molecules may be used as a polynucleotide vaccine which provides effective immunoprophylaxis against HIV infection through stimulation of neutralizing antibody and cell-mediated immunity.
Variant Hcmv Pp65, Ie1, And Ie2 Polynucleotides And Uses Thereof
Variant Hcmv Pp65, Ie1, And Ie2 Polynucleotides And Uses Thereof
US Patent:
2011013, Jun 9, 2011
Filed:
Jul 28, 2009
Appl. No.:
13/056899
Inventors:
Tong-Ming Fu - Maple Glen PA, US
Danilo R. Casimiro - Harleysville PA, US
Daniel C. Freed - Limerick PA, US
Aimin Tang - Landsdale PA, US
Danilo R. Casimiro - Harleysville PA, US
Daniel C. Freed - Limerick PA, US
Aimin Tang - Landsdale PA, US
International Classification:
A61K 31/7088, C07H 21/04, C07K 14/005, C12N 15/63, C12P 21/06
US Classification:
514 44 R, 536 2372, 530350, 4353201, 435 691
Abstract:
The present invention relates to compositions and methods to elicit or enhance cell-mediated immunity against HCMV infection by providing polynucleotides encoding variant HCMV pp65, IE1, and IE2 proteins, and fusion proteins thereof. The present invention also provides recombinant vectors including, but not limited to, adenovirus and plasmid vectors comprising said polynucleotides and host cells comprising said recombinant vectors. Also provided herein are purified forms of the variant HCMV pp65, IE1, and IE2 proteins described herein, and fusion proteins. The variant HCMV proteins, and fusion proteins thereof, are useful as vaccines for the protection from and/or treatment of HCMV infection. Said vaccines are useful as a monotherapy or a part of a therapeutic regime, said regime comprising administration of a second vaccine such as a polynucleotide, cell-based, protein or peptide-based vaccine.
Synthetic Hiv Gag Genes
Synthetic Hiv Gag Genes
US Patent:
2004018, Sep 16, 2004
Filed:
Oct 5, 2003
Appl. No.:
10/678926
Inventors:
John Shiver - Doylestown PA, US
Mary Davies - Norristown PA, US
Daniel Freed - Limerick PA, US
Margaret Liu - Rosemont PA, US
Helen Perry - Lansdale PA, US
Mary Davies - Norristown PA, US
Daniel Freed - Limerick PA, US
Margaret Liu - Rosemont PA, US
Helen Perry - Lansdale PA, US
International Classification:
C12Q001/70, C07H021/04, C07K014/16, C12N015/86
US Classification:
435/005000, 435/069300, 435/456000, 435/325000, 530/350000, 536/023720
Abstract:
Synthetic DNA molecules encoding HIV gag and modifications of HIV gag are provided. The codons of the synthetic molecules are codons preferred by the projected host cell. The synthetic molecules may be used as a polynucleotide vaccine which provides effective immunoprophylaxis against HIV infection through stimulation of neutralizing antibody and cell-mediated immunity.
Pd-1 Binding Proteins
Pd-1 Binding Proteins
US Patent:
8168757, May 1, 2012
Filed:
Mar 3, 2009
Appl. No.:
12/922066
Inventors:
Adam C. Finnefrock - Berwyn PA, US
Tong-Ming Fu - Maple Glen PA, US
Daniel C. Freed - Limerick PA, US
Danilo R. Casimiro - Harleysville PA, US
Fengsheng Li - Scarsdale NY, US
Aimin Tang - Lansdale PA, US
Tong-Ming Fu - Maple Glen PA, US
Daniel C. Freed - Limerick PA, US
Danilo R. Casimiro - Harleysville PA, US
Fengsheng Li - Scarsdale NY, US
Aimin Tang - Lansdale PA, US
Assignee:
Merck Sharp & Dohme Corp. - Rahway NJ
International Classification:
C07K 16/00
US Classification:
5303871
Abstract:
The present invention features PD-1 binding proteins, a subset of which inhibits binding of PD-L1 to the PD-1 receptor. These binding proteins can be employed to modulate the immune system through the manipulation of the PD-1 signaling pathway, enhancing host immunity to treat infections and cancer.