Inventors:
Srinivasa Madhyastha - Winnipeg, CA
Nanda Yakandawala - Winnipeg, CA
Purushottam V. Gawande - Winnipeg, CA
Karen Lovetri - Winnipeg, CA
Jeffrey B. Kaplan - Monsey NJ, US
Daniel Rhoads - Lubbock TX, US
Lasha Gogokhia - Lubbock TX, US
Assignee:
Kane Biotech Inc. - Winnipeg
International Classification:
A61K 38/47, A61K 9/14, A61K 38/44, A61P 31/00
US Classification:
424405, 424 9461, 424 944
Abstract:
The present invention provides compositions comprising an antibiofilm enzyme, a soluble β-N-acetylglucosaminidase similar to the dspB gene (DispersinB™), and an antimicrobial for preventing growth and proliferation of biofilm-embedded microorganisms in acute and chronic wounds, and methods of treatment. The invention further provides methods for preparing medical devices, and in particular, wound care devices using DispersinB™-based antimicrobial compositions.