Inventors:
Daniel D. Gretler - San Francisco CA, US
Pamela B. Conley - Palo Alto CA, US
Patrick Andre - San Mateo CA, US
Athiwat Hutchaleelaha - Redwood City CA, US
David R. Phillips - San Mateo CA, US
Anjali Pandey - Fremont CA, US
Robert M. Scarborough - Half Moon Bay CA, US
Carroll Anna Crew Scarborough - Half Moon Bay CA, US
Wolin Huang - Foster City CA, US
Assignee:
Portola Pharmaceuticals, Inc. - So. San Francisco CA
International Classification:
A61K 38/45, A61K 38/48, A61P 9/00, A61K 31/517, C07D 409/12, A61P 7/00, A61K 38/46, A61K 31/60
US Classification:
424 945, 424 946, 424 9464, 514165, 51426624, 544285
Abstract:
The invention provides methods and compositions for rapid and reversible inhibition of platelet aggregation in human subjects in need thereof by administering compounds of the formula:alone or in combination with a second agent which can be aspirin or a thrombolytic agent.