Inventors:
Simon E. Aspland - Baltimore MD, US
Dan E. Berkowitz - Baltimore MD, US
Trinity Bivalacqua - Baltimore MD, US
Hunter Champion - Baltimore MD, US
Assignee:
ARGINETIX, INC - Lutherville MD
International Classification:
A61K 31/69, A61K 31/50, A61K 31/4985, A61K 31/501, A61K 31/496, A61K 31/5025, A61K 31/519, A61K 31/522, A61K 31/506, A61K 31/4375, A61K 31/436, A61K 31/437, A61P 11/06, A61P 9/00, A61P 15/10, A61P 29/00, A61P 9/12, A61K 31/53
US Classification:
514 64, 514246, 514247, 514250, 51425203, 51425204, 51425216, 51425307, 514257, 5142621, 51426332, 514275, 514283, 514291, 514293, 514300
Abstract:
Compositions and methods of treating endothelial disorders, including: asthma, erectile dysfunction, pulmonary hypertension, cardiovascular disorders, and other disorders, using a synergistic combination of at least one arginase inhibitor and at least one phosphodiesterase (PDE1), (PDE2) and/or (PDE5) inhibitor are described.