DR. DAMIEN CRAIG RODGER, MD, PHD
Medical Practice in Los Angeles, CA

2006025, Nov 16, 2006

Apr 21, 2006

11/408809

Yu-Chong Tai - Pasadena CA, US
Damien Rodger - Los Angeles CA, US
Wen Li - Pasadena CA, US
Angela Tooker - Alhambra CA, US

California Institute of Technology - Pasadena CA

G21G 5/00, C23C 16/00

250492100, 118725000

Systems and methods for improving the adherence of poorly-adherent parylene-to-parylene films or layers and/or altering the water and chemical permeability of the parylene layers. A device having two or more parylene layers is heated in a reduced pressure treatment chamber at a temperature above the deposition temperature of the parylene (e.g., from about room temperature to several hundreds of degrees Celsius) for an extended period of time (e.g., a few hours up to several days). The methods of the present invention have been shown to convert poorly-adherent and/or water-permeable films to optimally-adherent and/or relatively water-impermeable films.

7338836, Mar 4, 2008

Oct 25, 2004

10/974006

Yu-Chong Tai - Pasadena CA, US
Damien C. Rodger - Los Angeles CA, US

California Institute of Technology - Pasadena CA

H01L 21/44

438106, 438107

A method for manufacturing integrated objects, e. g. , electronic devices, biological devices. The method includes providing a holder substrate, which has at least one recessed region, the recessed region having a predetermined shape. The holder substrate has a selected thickness and is characterized as being substantially rigid in shape. The method includes aligning a chip comprising a face and a backside into the predetermined shape of the recessed region and disposing the chip into the recessed region. The chip is secured into the recessed region. The method includes providing a first film of insulating material having a first thickness overlying the face and portions of the holder substrate to attach the chip to a portion of the first film of insulating material and patterning the first film of insulating material to form at least one opening through a portion of the first thickness to a contact region on the face of the chip. The method includes forming a metallization layer overlying the first film of insulating material to couple to the contact region through the one opening and forming a protective layer overlying the metallization layer. The method includes releasing the chip from the holder substrate while maintaining attachment of the chip to the first film of insulating material.

7600533, Oct 13, 2009

Aug 10, 2007

11/837450

Yu-Chong Tai - Pasadena CA, US
Damien C. Rodger - Los Angeles CA, US
Mark S. Humayun - Glendale CA, US

California Institute of Technology - Pasadena CA

F16K 15/14

13751625, 13753319, 137859

Micro check valves having a free-floating member for controlling flow of fluid in microfluidic and biomedical applications and methods of fabrication. A micro check valve includes a valve seat, a valve cap that contacts the valve seat and an untethered floating member that can move between the valve seat and the valve cap. Certain micro check valves have zero cracking pressure and no reverse leakage. Certain other valves may be configured to permit flow of fluid within a pressure range. The floating member can be solid or define an orifice, and the valve seat can have one or two levels. Valves can be configured to allow fluid to flow when the floating member is pushed by fluid against the valve cap or against the valve seat. The valve seat may be silicon or another material that is compatible with micromachining processes, and the valve cap and the floating member may be a polymer such as Parylene.

8141573, Mar 27, 2012

Sep 23, 2009

12/565636

Yu-Chong Tai - Pasadena CA, US
Damien C. Rodger - Los Angeles CA, US
Mark S. Humayun - Glendale CA, US

California Institute of Technology - Pasadena CA

F16K 15/00

137 1519, 13753319

Micro check valves having a free-floating member for controlling flow of fluid in microfluidic and biomedical applications and methods of fabrication. A micro check valve includes a valve seat, a valve cap that contacts the valve seat and an untethered floating member that can move between the valve seat and the valve cap. Certain micro check valves have zero cracking pressure and no reverse leakage. Certain other valves may be configured to permit flow of fluid within a pressure range. The floating member can be solid or define an orifice, and the valve seat can have one or two levels. Valves can be configured to allow fluid to flow when the floating member is pushed by fluid against the valve cap or against the valve seat. The valve seat may be silicon or another material that is compatible with micromachining processes, and the valve cap and the floating member may be a polymer such as Parylene.

7706887, Apr 27, 2010

Oct 31, 2007

11/933222

Yu-Chong Tai - Pasadena CA, US
Damien C. Rodger - Los Angeles CA, US

California Institute of Technology - Pasadena CA

A61N 1/18

607 54, 607 2, 257678, 623 663

A method (and resulting structure) for fabricating a sensing device. The method includes providing a substrate comprising a surface region and forming an insulating material overlying the surface region. The method also includes forming a film of carbon based material overlying the insulating material and treating to the film of carbon based material to pyrolyzed the carbon based material to cause formation of a film of substantially carbon based material having a resistivity ranging within a predetermined range. The method also provides at least a portion of the pyrolyzed carbon based material in a sensor application and uses the portion of the pyrolyzed carbon based material in the sensing application. In a specific embodiment, the sensing application is selected from chemical, humidity, piezoelectric, radiation, mechanical strain or temperature.

8246569, Aug 21, 2012

Aug 16, 2005

11/205757

Ellis Fan-chuin Meng - Pasadena CA, US
Damien Rodger - Los Angeles CA, US
Yu-Chong Tai - Pasadena CA, US
Mark Humayun - Glendale CA, US

California Institute of Technology - Pasadena CA

A61M 5/00

604 8, 604 9

An implanted parylene tube shunt relieves intra-ocular pressure. The device is implanted with an open end in the anterior chamber of the eye, allowing excess fluid to be drained through the tube out of the eye. In one embodiment, only a first end of the tube implanted into the anterior chamber of the eye is open. Intra-ocular pressure (IOP) is then monitored, for example utilizing an implanted sensor. When IOP exceeds a critical value, a practitioner intervenes, puncturing with a laser a thinned region of the tube lying outside the eye, thereby initiating drainage of fluid and relieving pressure. In accordance with alternative embodiments, the both ends of the tube are open, and the tube includes a one-way valve configured to permit drainage where IOP exceeds the critical value. The tube may include projecting barbs to anchor the tube in the eye without the need for sutures.

2006024, Nov 2, 2006

Mar 7, 2006

11/371219

Ellis Meng - Pasadena CA, US
Yu-Chong Tai - Pasadena CA, US
Damien Rodger - Los Angeles CA, US
Mark Humayun - Glendale CA, US

California Institute of Technology - Pasadena CA
University of Southern California - Los Angeles CA

A61F 2/02, A61B 3/16

606151000, 600398000

Systems and methods for attaching an implant device to tissue by mechanically (and non-invasively) anchoring the device to the tissue. The systems and methods provide a safe, practical way to attach an implant device to tissue in a non-invasive, or less invasive manner. According to the present invention, an implant device includes one or more protruding anchor-like structures for securely attaching to tissue. One or more device features, such as sensing elements, may be incorporated on the implant device. The anchor structures are configured and arranged to match the topology and features of the tissue environment where implant is to occur.

7684868, Mar 23, 2010

Nov 10, 2005

11/272382

Yu-Chong Tai - Pasadena CA, US
Damien C. Rodger - Los Angeles CA, US
Wen Li - Pasadena CA, US
Mark Humayun - Glendale CA, US
James D. Weiland - Valencia CA, US

California Institute of Technology - Pasadena CA

A61N 1/40

607 54

This invention relates to the design and fabrication of micro electromechanical systems (MEMS) for applications in such varied fields as the biomedical, micro-fluidics and chemical analysis fields.

8112157, Feb 7, 2012

Nov 10, 2005

11/272383

Yu-Chong Tai - Pasadena CA, US
Damien C. Rodger - Los Angeles CA, US
Wen Li - Pasadena CA, US

California Institute of Technology - Pasadena CA

A61N 1/05

607 53, 607 54, 607 60, 607 65

This disclosure relates to the design and fabrication of micro-electromechanical systems (MEMS) for applications in such varied fields as the biomedical, micro-fluidics and chemical analysis fields for wireless data and power transfer.

8585630, Nov 19, 2013

Jul 23, 2012

13/555329

Ellis Fan-chuin Meng - Pasadena CA, US
Damien Rodger - Los Angeles CA, US
Yu-Chong Tai - Pasadena CA, US
Mark Humayun - Glendale CA, US

California Institute of Technology - Pasadena CA

A61M 5/00

604 8, 604 9

An implanted parylene tube shunt relieves intra-ocular pressure. The device is implanted with an open end in the anterior chamber of the eye, allowing excess fluid to be drained through the tube out of the eye. In one embodiment, only a first end of the tube implanted into the anterior chamber of the eye is open. Intra-ocular pressure (IOP) is then monitored, for example utilizing an implanted sensor. When IOP exceeds a critical valve, a practitioner intervenes, puncturing with a laser a thinned region of the tube lying outside the eye, thereby initiating drainage of fluid and relieving pressure. In accordance with alternative embodiments, the both ends of the tube are open, and the tube includes a one-way valve configured to permit drainage where IOP exceeds the critical value. The tube may include projecting barbs to anchor the tube in the eye without the need for sutures.