DR. DALE T UMETSU, MD, PHD
Medical Practice at Longwood Ave, Boston, MA
License number
Massachusetts 49852
Category
Medical Practice
Type
Pediatric Allergy/Immunology
Address
Address
2
300 Longwood Ave, Boston, MA 02115
522 Dudley Rd, Newton, MA 02459
522 Dudley Rd, Newton, MA 02459
Phone
(617) 355-6617
(617) 527-2892
(617) 527-2892
Organization information
See more information about DALE T UMETSU at bizstanding.comDale T Umetsu MD
1 Blackfan Cir, Boston, MA 02115
Industry:
Medical Doctor's Office, Nonclassifiable Establishments
Phone:
(617) 919-2482 (Phone)
Categories:
Allergy & Immunology Physicians & Surgeons
Professional information
See more information about DALE T UMETSU at trustoria.com
Dr. Dale T Umetsu, Boston MA - MD (Doctor of Medicine)
Dr. Dale T Umetsu, Boston MA - MD (Doctor of Medicine)
Specialties:
Pediatrics, Allergy & Immunology
Address:
300 Longwood Ave, Boston 02115
(617) 355-6617 (Phone), (617) 730-0528 (Fax)
KARP LABS RM. 10127
1 Blackfan Cir SUITE 10TH, Boston 02115
(617) 335-4335 (Phone)
(617) 355-6617 (Phone), (617) 730-0528 (Fax)
KARP LABS RM. 10127
1 Blackfan Cir SUITE 10TH, Boston 02115
(617) 335-4335 (Phone)
Certifications:
Allergy & Immunology, 1985, Pediatrics, 1984
Awards:
Healthgrades Honor Roll
Languages:
English
Hospitals:
300 Longwood Ave, Boston 02115
KARP LABS RM. 10127
1 Blackfan Cir SUITE 10TH, Boston 02115
Stanford Hospital and Clinics
300 Pasteur Dr, Stanford 94305
KARP LABS RM. 10127
1 Blackfan Cir SUITE 10TH, Boston 02115
Stanford Hospital and Clinics
300 Pasteur Dr, Stanford 94305
Education:
Medical School
New York University
Graduated: 1979
Chldns Hosp/Harvard Ms
Graduated: 1980
Graduated: 1982
Graduated: 1984
New York University
Graduated: 1979
Chldns Hosp/Harvard Ms
Graduated: 1980
Graduated: 1982
Graduated: 1984
T Cell Regulatory Genes Associated With Immune Disease
T Cell Regulatory Genes Associated With Immune Disease
US Patent:
7838220, Nov 23, 2010
Filed:
Sep 15, 2003
Appl. No.:
10/663497
Inventors:
Jennifer Jones McIntire - Palo Alto CA, US
Rosemarie Dekruyff - Newton MA, US
Dale T. Umetsu - Newton MA, US
Gordon Freeman - Boston MA, US
Rosemarie Dekruyff - Newton MA, US
Dale T. Umetsu - Newton MA, US
Gordon Freeman - Boston MA, US
Assignee:
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
Dana-Farber Cancer Institute - Boston MA
Dana-Farber Cancer Institute - Boston MA
International Classification:
C12Q 1/68, C12P 19/34, C07H 21/04
US Classification:
435 6, 435 911, 536 243, 436 63
Abstract:
A genetic locus and corresponding family of proteins associated with regulation of immune development, function, and cell survival are provided. The locus comprising the TIM family is genetically associated with immune dysfunction, including atopy, autoimmunity, inflammatory bowel disease, dysplasia, and susceptibility to blood-bourne infectious diseases. Polymorphisms in the human TIM-1 gene and exposure to Hepatitis A Virus (HAV) are shown to be associated with protection from the development of atopy.
Methods For Inhibition Of Nkt Cells
Methods For Inhibition Of Nkt Cells
US Patent:
7682614, Mar 23, 2010
Filed:
Nov 2, 2005
Appl. No.:
11/266033
Inventors:
Samuel Strober - Stanford CA, US
Everett Hurteau Meyer - Redwood City CA, US
Dale T. Umetsu - Newton MA, US
Everett Hurteau Meyer - Redwood City CA, US
Dale T. Umetsu - Newton MA, US
Assignee:
The Board Of Trustees Of The Leland Stanford Junior University - Palo Alto CA
International Classification:
A61K 31/7028, A61K 39/395
US Classification:
4241441, 4241531, 514 25
Abstract:
Molecules that interact with the NKT cell antigen receptor and its counterpart antigen presenting molecule, but which inhibit the NKT cell immune function, are administered to a patient. Conditions of particular interest include the treatment of systemic lupus erythematosus (SLE), cancer, atherosclerosis, and allergic disease. In some embodiment of the invention, the inhibitory agent is an anergizing glycolipid, for example β-galactosylceramide. Pharmaceutical formulations of such glycolipids are provided, and find use in the treatment of diseases involving undesirable NKT cell activation.
Treatment Of Airway Hyperreactivity
Treatment Of Airway Hyperreactivity
US Patent:
2011030, Dec 8, 2011
Filed:
Aug 21, 2008
Appl. No.:
12/674191
Inventors:
Dale T. Umetsu - Newton MA, US
Muriel Pichavant - Mons-en-Baroeul, FR
Everett Hurteau Meyer - Redwood City CA, US
Stephanie Ann Shore - Lexington MA, US
Muriel Pichavant - Mons-en-Baroeul, FR
Everett Hurteau Meyer - Redwood City CA, US
Stephanie Ann Shore - Lexington MA, US
Assignee:
CHILDREN'S MEDICAL CENTER CORPORATION - Boston MA
PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY - Palto Alto CA
PRESIDENT AND FELLOWS OF HARVARD COLLEGE - Cambridge MA
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY - Palto Alto CA
International Classification:
A61K 39/395, A61K 31/7088, A61P 11/06, A61K 31/7028, A61P 37/06, A61K 38/17, A61K 31/713
US Classification:
4241581, 514 17, 4241721, 514 44 A, 4241841
Abstract:
The invention provides strategies for treating and preventing airway hyperreactivity and non-allergic asthma comprising antagonizing IL-17 activity and/or production by iNKT cells. Provided herein is a method of diagnosing non-allergic asthma and airway hyperreactivity comprising neutrophils quantification in sputum.
Modulation Of Tim Receptor Activity In Combination With Cytoreductive Therapy
Modulation Of Tim Receptor Activity In Combination With Cytoreductive Therapy
US Patent:
2012015, Jun 21, 2012
Filed:
Jul 5, 2011
Appl. No.:
13/176651
Inventors:
Jennifer Jones - Palo Alto CA, US
Rosemarie Dekruyff - Stanford CA, US
Dale T. Umetsu - Newton MA, US
Gordon J. Freeman - Boston MA, US
Susan Jane Knox - Stanford CA, US
Rosemarie Dekruyff - Stanford CA, US
Dale T. Umetsu - Newton MA, US
Gordon J. Freeman - Boston MA, US
Susan Jane Knox - Stanford CA, US
International Classification:
A61K 39/395, A61P 35/00
US Classification:
4241731
Abstract:
A genetic locus and corresponding family of proteins associated with regulation of immune function and cell survival are provided. These genes encode cell surface molecules with conserved IgV and mucin domains. The locus comprising the TIM family is genetically associated with immune dysfunction, including asthma. Furthermore, the TIM gene family is located within a region of human chromosome 5 that is commonly deleted in malignancies and myelodysplastic syndrome. Polymorphisms in the gene sequences are associated with the development of airway hyperreactivity and allergic inflammation, and T cell production of IL-4 and IL-13. The proteins include the human hepatitis A cellular receptor, hHAVcr-1.
Methods For Inhibition Of Nkt Cells
Methods For Inhibition Of Nkt Cells
US Patent:
2010019, Aug 5, 2010
Filed:
Feb 1, 2010
Appl. No.:
12/697882
Inventors:
Samuel Strober - Stanford CA, US
Everett Hurteau Meyer - Redwood City CA, US
Dale T. Umetsu - Newton MA, US
Everett Hurteau Meyer - Redwood City CA, US
Dale T. Umetsu - Newton MA, US
Assignee:
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY - PALO ALTO CA
International Classification:
A61K 31/7032, A61P 37/08, A61P 11/06, C12Q 1/02
US Classification:
514 25, 435 29
Abstract:
Molecules that interact with the NKT cell antigen receptor and its counterpart antigen presenting molecule, but which inhibit the NKT cell immune function, are administered to a patient. Conditions of particular interest include the treatment of systemic lupus erythematosus (SLE), cancer, atherosclerosis, and allergic disease. In some embodiment of the invention, the inhibitory agent is an anergizing glycolipid, for example β-galactosylceramide. Pharmaceutical formulations of such glycolipids are provided, and find use in the treatment of diseases involving undesirable NKT cell activation.
Production And Therapeutic Uses Of Th1-Like Regulatory T Cells
Production And Therapeutic Uses Of Th1-Like Regulatory T Cells
US Patent:
2008024, Oct 2, 2008
Filed:
Mar 18, 2005
Appl. No.:
11/908419
Inventors:
Dale Umetsu - Newton MA, US
Rosemarie Dekruyff - Newton MA, US
Omid Akbari - Los Altos CA, US
Philippe Stock - Berlin, DE
Rosemarie Dekruyff - Newton MA, US
Omid Akbari - Los Altos CA, US
Philippe Stock - Berlin, DE
Assignee:
The Board of Trustees of the Leland Stanford Junior University - Palo Alto CA
International Classification:
A61K 39/00, C12N 5/06
US Classification:
4241841, 435325
Abstract:
A unique CD4CD25 regulatory T cell population develops from naive CD4CD25 T cells during a T1 polarized immune response (called T1-Tcells). These T1-Tcells can be generated by contacting naïve T cells with mature CD8α dendritic cells (DCs) that have been exposed to a T1 polarizing adjuvant and, in some cases, an antigen of interest. The T1-Tare identified by their expression of the cytokines IL-10 and IFN-γ, the transcriptional regulators T-bet and FoxP3, and the cell surface molecules CD4, CD25, CD69, CD44 and ICOS.