Inventors:
Dai Yamanouchi - Madison WI, US
K. Craig Kent - Fitchburg WI, US
Bo Liu - Madison WI, US
Assignee:
Wisconsin Alumni Research Foundation - Madison WI
International Classification:
A61K 39/395, A61K 31/675, A61P 9/00, A61K 31/663
US Classification:
4241581, 514108, 514107, 514 89, 514 94
Abstract:
The present invention is directed to a method for treating aneurysms in vascular tissue. The method includes administering a bisphosphonate compound to a subject in an amount which is effective against the formation or progression of aneurysm, or which is effective to induce regression of an established aneurysm. In alternative methods, an anti-RANKL neutralizing antibody is administered to the subject to achieve analogous anti-aneurysm effect. The methods of particular advantage in the treatment of subjects having an abdominal aortic aneurysm, a relatively common, and life-threatening, condition.