DAGMARA A MOHUCZY
Medical Practice at 47 Way, Gainesville, FL
License number
Florida 39921
Issued Date
Jun 29, 2006
Effective Date
Jun 29, 2006
Expiration Date
Aug 31, 2018
Category
Health Care
Type
Clinical Laboratory Personnel
Address
Address
7845 NW 47Th Way, Gainesville, FL 32653
Phone
(352) 214-0427
Professional information
Antisense Oligonucleotide Compositions Targeted To Angiotensin Converting Enzyme Mrna And Methods Of Use
US Patent:
6248724, Jun 19, 2001
Filed:
Sep 25, 1998
Appl. No.:
9/162484
Inventors:
Mark D. Moore - Houston TX
M. Ian Phillips - Gainesville FL
Dagmara Mohuczy - Gainesville FL
M. Ian Phillips - Gainesville FL
Dagmara Mohuczy - Gainesville FL
Assignee:
University of Florida - Gainesville FL
International Classification:
A61K 3170, A01N 4304, C07H 2104, C12Q 168, C12N 500
US Classification:
514 44
Abstract:
Antisense oligonucleotides specific for mammalian ACE mRNA have been identified. Administration of these oligonucleotides to animals resulted in a decrease in blood pressure, but no significant change in heart rate. Methods for discovering other oligonucleotides with the same activity are taught, as are uses of the antisense molecules for treatment of human and animal diseases.
Antisense Nucleic Acids
US Patent:
2003022, Nov 27, 2003
Filed:
Mar 28, 2003
Appl. No.:
10/402099
Inventors:
M. Phillips - Gainesville FL, US
Dagmara Mohuczy - Gainesville FL, US
Dagmara Mohuczy - Gainesville FL, US
International Classification:
C12Q001/68, C07H021/04, A61K048/00
US Classification:
514/044000, 435/006000, 435/320100, 536/023500
Abstract:
Antisense oligonucleotides sequences that inhibit expression of anthrax toxin receptor (ATR) mRNA and human tumor endothelial marker 8 have been designed and constructed. The antisense oligonucleotides may be used to inhibit anthrax infection of host cells as well as for treating cancerous tumors. Introducing such antisense oligonucleotides into a cell decreases ATR expression and decreases tumor cell viability in vitro. Methods for discovering other oligonucleotides with the same activity are taught, as are uses of the antisense molecules for treatment of diseases.