Inventors:
Haydeh Payami - Slingerlands NY, US
Taye H. Hamza - Albany NY, US
Stewart A. Factor - Atlanta GA, US
John Nutt - Portland OR, US
Cyrus Zabetian - Seattle WA, US
Honglei Chen - Cary NC, US
Erin Hill Burns - Niskayuna NY, US
Assignee:
Health Research Inc. - Menands NY
Emory University School of Medicine - Atlanta GA
National Institute of Environmental Health Sciences - Research Triangle Park NC
Veterans Affairs Puget Sound Health Care System - Seattle WA
Oregon Health & Science University - Portland OR
International Classification:
C12Q 1/68, A61K 31/465, A61K 31/522, A61K 45/06
US Classification:
514165, 514343, 51426334, 514570, 514420, 514682, 514605, 514413, 514569, 514567, 514378, 514406, 544274, 5462794, 435 611
Abstract:
The present invention relates to methods of treatment for Parkinson Disease (PD) in a person by identifying gene variants which may indicate a more favorable response to specific medicaments, thereby allowing for personalized or individualized treatment. The present invention relates to a method of screening for a genetic predisposition to PD in a person. The present invention is also directed to a method of testing a person for the presence of particular gene variants, wherein the presence of a gene variant indicates a higher predisposition to PD, and the absence of a gene variant indicates a lower predisposition to PD, compared to a control sample. The present invention further relates to methods and kits for treating, or inhibiting the development of, PD in a person. The present invention is also directed to a method of identifying the heritage of an individual based on the genetic profile of the individual.