Inventors:
Cynthia L. Sears - Baltimore MD, US
Drew M. Pardoll - Brookeville MD, US
Shaoguang Wu - Lutherville MD, US
Franck Housseau - Ashburn VA, US
Assignee:
THE JOHNS HOPKINS UNIVERSITY - Baltimore MD
International Classification:
A61K 39/07, G01N 33/50, A61P 37/04, G01N 33/53, C07K 16/12, C12Q 1/68, G01N 33/68
US Classification:
4242461, 435 612, 436 94, 436 86, 436501, 5303895
Abstract:
The invention provides compositions and methods for useful for the diagnosis of inflammatory bowel disease, ETBF-induced colitis, colonic hyperplasia and/or colon carcinogenesis in a subject in biological samples (e.g., stool, urine, blood, serum, tissue). The invention further provides compositions and methods for the treatment or prevention of colitis, colon cancer, or inflammatory bowel disease (e.g., Crohn's disease).