Inventors:
Craig W. Carson - Edmond OK
Charles T. Esmon - Oklahoma City OK
Donald S. Houston - Oklahoma City OK
Assignee:
Oklahoma Medical Research Foundation - Oklahoma City OK
International Classification:
C07K 14435, C07K 14525
Abstract:
A method of treating patients to inhibit inflammation is disclosed. In the method, an effective amount of calmodulin, a calmodulin analogue or calmodulin receptor agonist is administered to a patient to inhibit production of tumor necrosis factor and/or augment elastase. In another method, an effective amount of calmodulin antagonist is administered to a patient to stimulate immune response or inhibit elastase release. In another embodiment, a diagnostic test is disclosed to be used on patient blood samples to determine individual propensity to regulate tumor necrosis factor and/or elastase by calmodulin, its analogues or receptor agonists.