DR. CRAIG RIGGS MALLOY, M.D.
Osteopathic Medicine in Dallas, TX

5951473, Sep 14, 1999

Jun 24, 1997

8/881756

A. Dean Sherry - Dallas TX
Navin Bansal - Coppell TX
Craig R. Malloy - Dallas TX

Board of Regents, The University of Texas System - Austin TX

A61B 5055

600420

New methods for rapid, noninvasive determination of sodium ion in vivo are described. The methods are useful for assessing liver and other organ injury based on a nuclear magnetic resonance determination of intracellular and extracellular sodium in the damaged tissue. A shift reagent, TmDOTP. sup. 5-, is used in vivo to produce baseline resolved peaks of. sup. 23 Na. Excellent results are achieved with significantly less TmDOTP. sup. 5- than with other conventional. sup. 23 Na shift reagents such as DyTTHA. sup. 3-. In contrast to use in isolated perfused heart tissue, TmDOTP. sup. 5- solutions are employed in vivo without added calcium ion. The method has been applied to animal burn models. Results show that intracellular sodium ion levels are dramatically increased, thus providing a rapid assessment of liver function. Similar methods may be applied to the determination of intra- and extracellular potassium ion.

5597548, Jan 28, 1997

Jul 3, 1995

8/497779

A. Dean Sherry - Dallas TX
Piyu Zhao - Dallas TX
Craig R. Malloy - Dallas TX

Board of Regents, The University of Texas System - Austin TX

A61K 5104, C12Q 100, C12Q 102, C12Q 104

424 93

Entry of. sup. 13 C-enriched acetyl-CoA into the citric acid cycle results in scrambling of. sup. 13 C into the various carbon positions of all intermediate pools. The eventual result is that the. sup. 13 C resonances of all detectable intermediates or molecules exchanging with those intermediates appear as multiplets due to nearest neighbor spin-spin couplings. Isotopomer analysis of the glutamate. sup. 13 C multiplets provides a history of. sup. 13 C flow through the cycle pools. Relative substrate utilization and relative anaplerotic flux can be quantitated. A major limitation of the method for in vivo applications is spectral resolution of multi-line resonances required for a complete isotopomer analysis. It is now shown that (. sup. 13 C)homonuclear decoupling of the glutamate C3 resonance collapses nine-line C4 and C2 resonances into three line multiplets.

5413917, May 9, 1995

Jul 18, 1990

7/555270

Craig R. Malloy - Dallas TX
F. Mark H. Jeffrey - Dallas TX
A. Dean Sherry - Dallas TX

Board of Regents, The University of Texas System - Austin TX

C12Q 100, C12Q 102, C12Q 104

435 35

The present invention relates to a method of measuring the contribution of one or more exogenously administered. sup. 13 C-labeled substrates to acetyl-CoA. The measurement can be made in a tissue or cell using. sup. 13 C NMR without the constraint of metabolic or isotopic steady-state. Furthermore, the method permits the determination even when spectral lines are broad due to B. sub. 0 inhomogeneity, thereby opening the way for substrate utilization studies in vivo. The method does not require many of the simplifying assumptions involved in. sup. 11 C or. sup. 14 C methods, and, since a stable isotope,. sup. 13 C, is used a wide variety of compounds with complex labeling patterns may be synthesized and studied.

7256047, Aug 14, 2007

May 1, 2001

09/846727

Craig R. Malloy - Dallas TX, US
A. Dean Sherry - Dallas TX, US
John G. Jones - Coimbra, PT

Board of Regents, The University of Texas System - Austin TX

G01N 23/02

436 56, 436 57, 436173, 435 14, 435 72, 435105

The present invention provides a combination of carbon-13 and deuterium metabolic tracers and methods that when used in conjunction with nuclear magnetic resonance spectroscopy, provide a measurement of metabolic fluxes in the target organisms. The tracers of the present invention may be taken orally during the same clinical exam. The metabolic information can be derived from blood, urine or other fluids to provide a comprehensive profile of glucogenic metabolism. The subject matter of the present invention may be applied to the study of metabolic dysfunction related to obesity, diabetes, HIV infection and a variety of other disease conditions.

2013011, May 9, 2013

Sep 17, 2012

13/621567

Matthew E. Merritt - Euless TX, US
Craig R. Malloy - Dallas TX, US

The United States Government as represented by the Department of Veteran Affairs - Washington DC
The Board of Regents of the University of Texas System - Austin TX

A61B 5/055, A61B 5/00

600420

Methods and composition for metabolic imaging are provided. For example, in certain aspects, methods for hyperpolarization transfer combined with hyperpolarization are provided. Furthermore, the invention provides methods for detecting magnetic resonance signals for biological processes such as anaplerosis.