CRAIG N ZIMMERMAN
Broker in Topsfield, MA
License number
Massachusetts 9082751
Issued Date
Sep 29, 2005
Expiration Date
Jan 31, 2008
Type
Salesperson
Address
Address
Topsfield, MA 01983
Professional information
Cell Adhesion Inhibitors
US Patent:
6239108, May 29, 2001
Filed:
Aug 10, 1998
Appl. No.:
8/983391
Inventors:
Ko-Chung Lin - Lexington MA
Steven P. Adams - Andover MA
Alfredo C. Castro - Woburn MA
Craig N. Zimmerman - Topsfield MA
Julio Hernan Cuervo - Arlington MA
Charles E. Hammond - Burlington MA
Mary Beth Carter - Belmont MA
Ronald G. Almquist - Lexington MA
Steven P. Adams - Andover MA
Alfredo C. Castro - Woburn MA
Craig N. Zimmerman - Topsfield MA
Julio Hernan Cuervo - Arlington MA
Charles E. Hammond - Burlington MA
Mary Beth Carter - Belmont MA
Ronald G. Almquist - Lexington MA
Assignee:
Biogen, Inc. - Cambridge MA
International Classification:
A61K 3800, C07K 500, C07K 700
US Classification:
514 15
Abstract:
The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
Inhibitors Of Carbonic Anhydrase Ix
US Patent:
2009017, Jul 9, 2009
Filed:
Jan 8, 2009
Appl. No.:
12/350894
Inventors:
Craig Zimmerman - Topsfield MA, US
John W. Babich - Cambridge MA, US
John Joyal - Melrose MA, US
Genliang Lu - Winchester MA, US
Kevin P. Maresca - Tewksbury MA, US
Chris Barone - Roxbury Crossing MA, US
John W. Babich - Cambridge MA, US
John Joyal - Melrose MA, US
Genliang Lu - Winchester MA, US
Kevin P. Maresca - Tewksbury MA, US
Chris Barone - Roxbury Crossing MA, US
International Classification:
A61K 49/00, C07F 15/00, A61K 31/555, A61P 35/00
US Classification:
424 91, 546 10, 514185
Abstract:
Novel radiopharmaceuticals that are useful in diagnostic imaging and therapeutic treatment of disease characterized by over expression of CA-IX comprise a complex that contains a sulfonamide moiety which is capable of binding the active catalytic site of CA-IX, and a radionuclide adapted for radioimaging and/or radiotherapy:
Ca-Ix Specific Radiopharmaceuticals For The Treatment And Imaging Of Cancer
US Patent:
8211402, Jul 3, 2012
Filed:
Dec 4, 2009
Appl. No.:
12/631343
Inventors:
John W. Babich - Cambridge MA, US
Craig Zimmerman - Topsfield MA, US
John Joyal - Melrose MA, US
Kevin P. Maresca - Tewksbury MA, US
Genliang Lu - Winchester MA, US
Shawn Hillier - Danvers MA, US
Craig Zimmerman - Topsfield MA, US
John Joyal - Melrose MA, US
Kevin P. Maresca - Tewksbury MA, US
Genliang Lu - Winchester MA, US
Shawn Hillier - Danvers MA, US
Assignee:
Molecular Insight Pharmaceuticals, Inc. - Cambridge MA
International Classification:
A61K 51/04, A61K 31/444, A61K 31/555, A61K 49/00, C07D 401/12, C07F 13/00, A61P 35/00
US Classification:
424 165, 424 91, 514184, 514188, 514332, 514492, 534 14, 546 10, 546 12, 546265, 546 5, 548104, 548109, 556 1, 556 50
Abstract:
A compound that recognizes and binds to the CA-IX protein has Formula I, II, III, or IV. The compounds may include a radioactive element for radioimaging or therapeutic applications. Thus, pharmaceutical compositions may be prepared with one or more of the compounds of Formula I, II, III, or IV.
Radiolabeled Derivatives Of Potent Chymase Inhibitors
US Patent:
2009016, Jul 2, 2009
Filed:
Dec 18, 2008
Appl. No.:
12/338426
Inventors:
John W. Babich - Cambridge MA, US
William C. Eckelman - Cambridge MA, US
John Joyal - Melrose MA, US
Craig Zimmerman - Topsfield MA, US
William C. Eckelman - Cambridge MA, US
John Joyal - Melrose MA, US
Craig Zimmerman - Topsfield MA, US
International Classification:
A61K 51/00, C07D 333/52, C07F 9/28
US Classification:
424 189, 549 6, 548412, 424 185
Abstract:
Methods of imaging tissue of a mammal which expresses chymase include administering to the mammal an effective amount of a radiolabeled chymase inhibitor. Radiopharmaceuticals that may be used in diagnostic imaging and therapeutic treatment of disease characterized by expression of chymase have the structure of Formula I:
Process For Production Of Heterodimers Of Glutamic Acid
US Patent:
2014003, Jan 30, 2014
Filed:
May 9, 2013
Appl. No.:
13/890912
Inventors:
Craig ZIMMERMAN - Topsfield MA, US
Kevin P. MARESCA - Tewksbury MA, US
Kevin P. MARESCA - Tewksbury MA, US
Assignee:
Molecular Insight Pharmaceuticals, Inc. - Cambridge MA
International Classification:
A61K 51/04
US Classification:
424 185, 556 41
Abstract:
A manufacturing process for the preparation of radiolabeled compounds of formula (I)includes reacting compounds of formula (II) with a source of readionuclide of a halogen in the presence of an oxidant under acidic condition,
Selective Seprase Inhibitors
US Patent:
2010009, Apr 22, 2010
Filed:
Sep 24, 2009
Appl. No.:
12/566324
Inventors:
Craig ZIMMERMAN - Topsfield MA, US
John W. Babich - Cambridge MA, US
John Joyal - Melrose MA, US
John Marquis - Nashua NH, US
Jian-cheng Wang - Revere MA, US
John W. Babich - Cambridge MA, US
John Joyal - Melrose MA, US
John Marquis - Nashua NH, US
Jian-cheng Wang - Revere MA, US
International Classification:
A61K 51/04, A61K 31/69, A61K 31/555, A61K 31/40, C07F 13/00, A61P 35/00
US Classification:
424 185, 424 165, 514 64, 514184, 514423, 544225, 546 12, 548402
Abstract:
Novel radiopharmaceuticals that are useful in diagnostic imaging and therapeutic treatment of disease characterized by overexpression of seprase include complexes that contains a proline moiety and a radionuclide adapted for radioimaging and/or radiotherapy:
Synthesis Of Cox-2 And Faah Inhibitors
US Patent:
2005023, Oct 20, 2005
Filed:
Nov 1, 2004
Appl. No.:
10/979794
Inventors:
Wilmin Bartolini - Amesbury MA, US
Brian Cali - Arlington MA, US
Barbara Chen - Watertown MA, US
Mark Currie - Sterling MA, US
G. Milne - Brookline MA, US
James Pearson - Cambridge MA, US
John Talley - Somerville MA, US
Craig Zimmerman - Topsfield MA, US
Brian Cali - Arlington MA, US
Barbara Chen - Watertown MA, US
Mark Currie - Sterling MA, US
G. Milne - Brookline MA, US
James Pearson - Cambridge MA, US
John Talley - Somerville MA, US
Craig Zimmerman - Topsfield MA, US
International Classification:
C07D043/02, C07D209/18
US Classification:
548465000, 548494000
Abstract:
Methods for preparing indoles that are useful COX-2 inhibitors and intermediates useful in such methods are described.
Inhibitors Of Integrin Vla-4
US Patent:
2009018, Jul 16, 2009
Filed:
Dec 10, 2008
Appl. No.:
12/331747
Inventors:
Craig N. ZIMMERMAN - Topsfield MA, US
John W. BABICH - Cambridge MA, US
John W. BABICH - Cambridge MA, US
International Classification:
A61K 51/00, C07F 13/00, A61P 29/00
US Classification:
424 165, 534 14
Abstract:
A complex, its stereoisomer or pharmaceutically acceptable salt has the formula I, where:
Modulators Of Crth2 Activity
US Patent:
7205329, Apr 17, 2007
Filed:
Jul 18, 2005
Appl. No.:
11/183626
Inventors:
G. Todd Milne - Brookline MA, US
Mark G. Currie - Sterling MA, US
John Jeffrey Talley - Somerville MA, US
Brian M. Cali - Arlington MA, US
Barbara Chen - Braintree MA, US
Craig Zimmerman - Topsfield MA, US
Jing Jing Yang - Boxborough MA, US
Mark G. Currie - Sterling MA, US
John Jeffrey Talley - Somerville MA, US
Brian M. Cali - Arlington MA, US
Barbara Chen - Braintree MA, US
Craig Zimmerman - Topsfield MA, US
Jing Jing Yang - Boxborough MA, US
Assignee:
Microbia, Inc. - Cambridge MA
International Classification:
A61K 31/405, C07D 209/12
US Classification:
514415, 548469
Abstract:
Modulators of the CRTH2 receptor and their use in the treatment of various disorders, including asthma are described.
Modulators Of Crth2, Cox-2 And Faah
US Patent:
2005023, Oct 20, 2005
Filed:
Jan 3, 2005
Appl. No.:
11/028896
Inventors:
Wilmin Bartolini - Amesbury MA, US
Brian Cali - Arlington MA, US
Barbara Chen - Watertown MA, US
Mark Currie - Sterling MA, US
G. Milne - Brookline MA, US
James Pearson - Cambridge MA, US
John Talley - Somerville MA, US
Jing Yang - Boxborough MA, US
Craig Zimmerman - Topsfield MA, US
Brian Cali - Arlington MA, US
Barbara Chen - Watertown MA, US
Mark Currie - Sterling MA, US
G. Milne - Brookline MA, US
James Pearson - Cambridge MA, US
John Talley - Somerville MA, US
Jing Yang - Boxborough MA, US
Craig Zimmerman - Topsfield MA, US
International Classification:
A61K031/53, A61K031/501, A61K031/497, A61K031/541, A61K031/5377, A61K031/496, C07D043/02, C07D417/02, C07D413/02
US Classification:
514183000, 514241000, 514252060, 514255050, 544238000, 544209000, 544405000, 548495000, 514419000, 514227500, 514232200, 514254050, 544060000, 544373000, 544143000, 514406000, 514365000, 514374000, 514414000
Abstract:
Certain substituted indoles that are modulators of one or more or of CRTH2, COX-2 AND FAAH are described. The compounds are useful for treatment of pain and/or inflammation as well as other disorders.