Inventors:
George R. Pettit - Paradise Valley AZ, US
Collin R. Anderson - Latham NY, US
International Classification:
A61K 31/4025, C07D 405/12, A61P 35/00, A61P 35/02, A61P 31/04
Abstract:
The present invention provides stilbene derived compounds having antineoplastic and/or antimicrobial activity. Preferred compounds of the invention include compounds of the formula (I) wherein R is Dap, Dap-Dil, Dap-Dil-Val, or Dap-Dil-Val-Dov; Ris H, OH, or PONa; and Rand Rare jointly —CH— or each independently H, OH, CH, or PONa; and compounds of the formulas (II), (III) and salts thereof, wherein R and Rare independently H or P(O)(OH). The present invention is further directed to methods of inhibiting cancer cell growth and/or microbial growth and compositions for use therewith.