DR. CLIFTON W CALLAWAY, MD
Medical Practice at Mckee Pl, Pittsburgh, PA

6438419, Aug 20, 2002

Sep 28, 2000

09/672647

Clifton W. Callaway - Pittsburgh PA
Lawrence D. Sherman - Aspinwall PA

The University of Pittsburgh - Pittsburgh PA

A61N 139

607 5, 600508

A defibrillator, which selectively delivers a defibrillation pulse to a patient, includes electrodes adapted for placement on the patient, a monitoring circuit for providing an electrocardiogram (ECG) of the patient, and a defibrillation pulse generator having an energy store for delivering a defibrillation pulse. A switch in electrical communication with the ECG monitoring circuit and the defibrillation pulse generator selectively electrically connects the monitoring circuit and the defibrillation pulse generator to the electrodes. A microprocessor is in electrical communication with the monitoring circuit, the defibrillation pulse generator, and the switch. The microprocessor causes the switch to electrically connect the monitoring circuit to the electrodes in order to provide the ECG of the patient. The microprocessor also determines a scaling exponent for the patient from the ECG thereof. The microprocessor further compares the scaling exponent to a predetermined value and selectively causes the switch to electrically connect the defibrillation pulse generator to the electrodes in order that the energy store delivers the defibrillation pulse to the patient.

8165673, Apr 24, 2012

Sep 23, 2008

12/236250

Lawrence D. Sherman - Bellevue WA, US
Clifton W. Callaway - Pittsburgh PA, US
James J. Menegazzi - Pittsburgh PA, US

University of Pittsburgh—of the Commonwealth System of Higher Education - Pittsburgh PA

A61N 1/39

607 5, 607 4, 600512, 600515, 600518, 600523, 128920

A defibrillation system for use in treatment of ventricular fibrillation includes at least one sensor to measure heart rhythm; at least one applicator to apply a defibrillation pulse to a patient; and at least one processor in communication with the sensor and the applicator to determine a first value related to the rate of change of a leading edge of a lagged phase space reconstruction of ventricular fibrillation heart rhythm measured over a period of time.

7444179, Oct 28, 2008

Apr 29, 2004

10/834412

Lawrence D Sherman - Pittsburgh PA, US
Clifton W Callaway - Pittsburgh PA, US
James J. Menegazzi - Pittsburgh PA, US

University of Pittsburgh-Of the Commonwealth System of Higher Education - Pittsburgh PA

A61B 5/046

600518, 607 5, 600512, 600515, 600523, 128920

A method of determining a state of ventricular fibrillation, includes: measuring the rhythm of the heart during ventricular fibrillation for a period of time; creating a lagged phase space reconstruction of the measured rhythm; determining a first value related to the rate of change of the leading edge of the phase space reconstruction over the period of time; and determining the state of ventricular fibrillation by relating the first value to the state of ventricular fibrillation. A defibrillation system includes at least one processor in communication with a sensor to measure heart rhythm and an applicator to apply a defibrillation pulse. The processor is adapted to create a lagged phase space reconstruction of ventricular fibrillation heart rhythm and to determine a first value related to the rate of change of the leading edge of the phase space reconstruction over a period of time.

6174875, Jan 16, 2001

Apr 1, 1999

9/282611

Donald B. DeFranco - Pittsburgh PA
Clifton W. Callaway - Pittsburgh PA
Christopher Lipinski - Pittsburgh PA
Nianqing Xiao - Pittsburgh PA

University of Pittsburgh - Pittsburgh PA

A61K 3133

514183

The present invention provides a method of inhibiting oxidative-stress induced cell death in a cell comprising contacting the cell with a composition comprising a benzoquinoid ansamycin. The present invention further provides a method of reducing neurological injury resulting from cardiac arrest or stroke comprising administering to a patient a composition comprising a benzoquinoid ansamycin.