Inventors:
Andrew J. Dannenberg - New York NY, US
Kotha Subbaramaiah - New Hyde Park NY, US
Clifford Hudis - New York NY, US
Assignee:
MEMORIAL SLOAN-KETTERING CANCER CENTER - New York NY
CORNELL UNIVERSITY - Ithaca NY
International Classification:
G01N 33/50
Abstract:
Chronic inflammation increases the risk of several epithelial malignancies. The present invention provides methods for determining cancer risk in a patient which comprises detecting the presence of crown-like structures (CLS), methods for treating cancer associated with CLS presence, methods for determining cancer risk in a patient by quantifying the number of CLS in a sample of adipose tissue of the patient, methods of determining prognosis of a patient with breast cancer or other cancers by detecting CLS, and screening methods for anti-cancer agents or agents that inhibit or reduce CLS formation or consequences thereof.