Inventors:
Michael B. Kastan - Cordova TN, US
Clay F. Semenkovich - Ladue MO, US
Jochen Schneider - St. Louis MO, US
Assignee:
St Jude Children's Research Hospital - Memphis TN
The Washington University - St. Louis MO
International Classification:
A61K 31/47
Abstract:
The present invention provides methods and compositions for modulating certain metabolic processes and for treating a variety of disorders associated with metabolic syndrome, including insulin related disorders, ischemia, oxidative stress, atherosclerosis, hypertension, obesity, abnormal lipid metabolism, and stroke by administering an effective dose of a chloroquine compound. The invention also provides methods and compositions relating to administering an effective dose of a chloroquine compound in combination with at least a second pharmaceutically active ingredient or compound including an antihyperglycemic diabetes treatment, an antihypertensive agent, an antithrombotic agent, and/or an inhibitor of cholesterol synthesis or absorption.