DR. CLAUDIO GARCIA BRUNSTEIN, M.D., PHD
Osteopathic Medicine in Minneapolis, MN
License number
Minnesota 44651
Category
Osteopathic Medicine
Type
Internal Medicine
License number
Minnesota 44651
Category
Osteopathic Medicine
Type
Hematology & Oncology
Address
Address
SE Pwb Fifth Floor, Minneapolis, MN 55455
Phone
(612) 273-2800
(612) 624-0123
(612) 625-6919 (Fax)
(612) 624-0123
(612) 625-6919 (Fax)
Personal information
See more information about CLAUDIO GARCIA BRUNSTEIN at radaris.comName
Address
Phone
221 Groveland Ave, Minneapolis, MN 55403
Minneapolis, MN
1117 Marquette Ave, Minneapolis, MN 55403
221 Groveland Ave, Minneapolis, MN 55403
1314 Marquette Ave, Minneapolis, MN 55403
Professional information
See more information about CLAUDIO GARCIA BRUNSTEIN at trustoria.com
Dr. Claudio G Brunstein, Burnsville MN - MD (Doctor of Medicine)
Dr. Claudio G Brunstein, Burnsville MN - MD (Doctor of Medicine)
Specialties:
Hematology
Address:
201 E Nicollet Blvd, Burnsville 55337
(952) 892-2000 (Phone)
5200 Fairview Blvd, Wyoming 55092
(651) 982-7000 (Phone)
516 Delaware St SE, Minneapolis 55455
(612) 626-2663 (Phone)
Fairview Northland Medical Center
911 Northland Dr, Princeton 55371
(763) 389-1313 (Phone)
(952) 892-2000 (Phone)
5200 Fairview Blvd, Wyoming 55092
(651) 982-7000 (Phone)
516 Delaware St SE, Minneapolis 55455
(612) 626-2663 (Phone)
Fairview Northland Medical Center
911 Northland Dr, Princeton 55371
(763) 389-1313 (Phone)
Procedures:
Bone Marrow Biopsy, Bone Marrow Transplant, HPC Transplantation (Stem Cell Transplant)
Conditions:
Acute Leukemia, Anemia, Antiphospholipid Syndrome (APS), Chronic Myeloid Leukemia (CML), Deep Vein Thrombosis (DVT), Immune Thrombocytopenic Purpura (ITP), Lymphoma, Myelodysplastic Syndromes, Myeloma, Myeloproliferative Disorders, Neutropenia, Non-Hodgkin's Lymphoma, Pancytopenia, Polycythemia Rubra Vera, Primary Hypercoagulable State (incl. Factor Lieden Disease), Venous Embolism and Thrombosis
Languages:
English
Hospitals:
201 E Nicollet Blvd, Burnsville 55337
516 Delaware St SE, Minneapolis 55455
5200 Fairview Blvd, Wyoming 55092
Fairview Northland Medical Center
911 Northland Dr, Princeton 55371
University of Minnesota Medical Center Fairview - West Bank
2312 6Th St South, Minneapolis 55454
516 Delaware St SE, Minneapolis 55455
5200 Fairview Blvd, Wyoming 55092
Fairview Northland Medical Center
911 Northland Dr, Princeton 55371
University of Minnesota Medical Center Fairview - West Bank
2312 6Th St South, Minneapolis 55454
Education:
Residency Hospital
University Of Mn Med School
University Of Mn Med School
Claudio Garcia Brunstein, Minneapolis MN
Claudio Garcia Brunstein, Minneapolis MN
Specialties:
Hematologist
Address:
420 Delaware St Se, Minneapolis, MN 55455
516 Delaware St Se, Minneapolis, MN 55455
516 Delaware St Se, Minneapolis, MN 55455
Compositions And Methods For Cxcr4 Signaling And Umbilical Cord Blood Stem Cell Engraftment
Compositions And Methods For Cxcr4 Signaling And Umbilical Cord Blood Stem Cell Engraftment
US Patent:
2013023, Sep 12, 2013
Filed:
Feb 27, 2013
Appl. No.:
13/779092
Inventors:
University of Virginia Patent Foundation, d/b/a University of Virginia Licensing & Ventures Group - , US
Mariusz Z. RATAJCZAK - Charlottesville VA, US
Claudio BRUNSTEIN - Minneapolis MN, US
Mariusz Z. RATAJCZAK - Charlottesville VA, US
Claudio BRUNSTEIN - Minneapolis MN, US
Assignee:
University of Virginia Patent Foundation, d/b/a University of Virginia Licensing & Ventures Group - Charlottesville VA
International Classification:
A61K 35/28
US Classification:
424 937
Abstract:
The present invention provides for enhancing engraftment by co-infusing at least two partially HLA matched umbilical cord blood (“UCB”) units. The invention further provides for positive C3a mediated priming on responsiveness to doses of SDF-1 and C3a induced incorporation of CXCR4 in membranes in HSC and progenitors. The invention further provides for enhancing the homing of UCB HSC and progenitors via the SDF-1/CXCR4 pathway and that C3a and LL-37 are useful for this method. It is also disclosed herein that fragments of C3a (e.g., des-Arg) are effective in the methods of the invention, including enhancing homing of HSPCs to BM. The invention further encompasses the disclosure herein of NFAT1 regulation post-transcriptionally by both mir-184 and IFN-γ. The present invention further provides for measuring and using differences between UCB and adult CD4+/45RA+ T-cells as a means of defining strategies to enhance optimal allogeneic stem cell transplantation outcomes. The present invention further provides methods for maintaining IL-2 production in the absence of NFAT1 normal protein levels.