Inventors:
Clark W. Distelhorst - Shaker Heights OH, US
Yiping Rong - Cleveland OH, US
International Classification:
A61K 38/00, C07K 7/00, C07K 14/00, A61P 43/00, G01N 33/00, C12N 5/06
US Classification:
514 12, 530330, 530329, 530328, 530327, 530326, 530325, 530324, 435375, 514 2, 514 13, 514 14, 514 15, 514 16, 514 17, 436 86
Abstract:
A purified polypeptide includes about 5 to about 80 amino acids and includes an amino acid sequence corresponding to a portion of SEQ ID NO:1. The polypeptide inhibiting binding of Bcl-2 to IPreceptors of cells that express IPR and Bcl-2.