Christopher W Ajello
Nursing in Lansdale, PA
License number
Pennsylvania RN638131
Category
Nursing
Type
Registered Nurse
Address
Address
Lansdale, PA 19446
Personal information
See more information about Christopher W Ajello at radaris.comName
Address
Phone
1501 E Hunting Park Ave, Philadelphia, PA 19124
1222 Howard St, Philadelphia, PA 19147
707 Garfield Ave, Lansdale, PA 19446
1501 Hunting Park Ave, Philadelphia, PA 19124
Professional information
See more information about Christopher W Ajello at trustoria.com
Spirocyclic Heterocyclic Derivatives And Methods Of Their Use
Spirocyclic Heterocyclic Derivatives And Methods Of Their Use
US Patent:
2005015, Jul 21, 2005
Filed:
Oct 1, 2004
Appl. No.:
10/957554
Inventors:
Roland Dolle - King of Prussia PA, US
Bertrand Le Bourdonnec - East Fallowfield PA, US
Christopher Ajello - Lansdale PA, US
Minghua Gu - Collegeville PA, US
Guo-Hua Chu - Wilmington DE, US
Paul Tuthill - Newark DE, US
Lara Leister - Shillington PA, US
Bertrand Le Bourdonnec - East Fallowfield PA, US
Christopher Ajello - Lansdale PA, US
Minghua Gu - Collegeville PA, US
Guo-Hua Chu - Wilmington DE, US
Paul Tuthill - Newark DE, US
Lara Leister - Shillington PA, US
International Classification:
A61K031/55, A61K031/4747, C07D491/10
US Classification:
514278000, 546015000, 514212020
Abstract:
Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ opioid receptor-mediated conditions.
Sulfonylamino Phenylacetamide Derivatives And Methods Of Their Use
Sulfonylamino Phenylacetamide Derivatives And Methods Of Their Use
US Patent:
2004025, Dec 16, 2004
Filed:
Jun 10, 2003
Appl. No.:
10/458135
Inventors:
Bertrand Le Bourdonnec - East Fallowfield PA, US
Christopher Ajello - Lansdale PA, US
Roland Dolle - King of Prussia PA, US
Christopher Ajello - Lansdale PA, US
Roland Dolle - King of Prussia PA, US
International Classification:
A61K031/55, A61K031/454, A61K031/4025, C 07D 4 3/02
US Classification:
514/210200, 514/217080, 514/326000, 514/408000, 514/422000, 540/602000, 546/208000, 548/517000, 548/571000
Abstract:
Sulfonylamino phenylacetamide derivatives of the general formula
are disclosed. Pharmaceutical compositions containing the compounds and methods for their use are also disclosed. In certain embodiments, the compounds of the invention that, preferably: (1) bind with high affinity to opioid receptors; (2) display good opioid receptor selectivity of versus and versus ; and (3) do not substantially inhibit cytochrome P450 enzymatic activity, in particular CYP2D6, CYP2C9 and CYP3A4.
Spirocyclic Heterocyclic Derivatives And Methods Of Their Use
Spirocyclic Heterocyclic Derivatives And Methods Of Their Use
US Patent:
7563802, Jul 21, 2009
Filed:
Dec 20, 2007
Appl. No.:
11/960845
Inventors:
Roland E. Dolle - King of Prussia PA, US
Bertrand Le Bourdonnec - East Fallowfield PA, US
Christopher W. Ajello - Lansdale PA, US
Minghua Gu - Collegeville PA, US
Guo-Hua Chu - Wilmington DE, US
Lara K. Leister - Shillington PA, US
Bertrand Le Bourdonnec - East Fallowfield PA, US
Christopher W. Ajello - Lansdale PA, US
Minghua Gu - Collegeville PA, US
Guo-Hua Chu - Wilmington DE, US
Lara K. Leister - Shillington PA, US
Assignee:
Adolor Corporation - Exton PA
International Classification:
A61K 31/438, C07D 491/10
US Classification:
514278, 546 17
Abstract:
Spirocyclic heterocyclic derivatives, pharmaceutical compositions containing these compounds, and methods for their pharmaceutical use are disclosed. In certain embodiments, the spirocyclic heterocyclic derivatives are ligands of the δ opioid receptor and may be useful, inter alia, for treating and/or preventing pain, anxiety, gastrointestinal disorders, and other δ opioid receptor-mediated conditions.