CHRISTOPHER SCOTT EVANS, D.O.
Osteopathic Medicine at Miranda Ave, Palo Alto, CA

License number

California 172983

Professional information

Metorphamide--A Novel Morphine-Like Peptide

US Patent:

4490363, Dec 25, 1984

Filed:

Jun 24, 1983

Appl. No.:

6/508140

Inventors:

Jack D. Barchas - Stanford CA
Eckard Weber - Palo Alto CA
Christopher J. Evans - Palo Alto CA

Assignee:

Board of Trustees of The Leland Stanford Junior University Stanford Univ. - Stanford CA

International Classification:

A61K 3700, C07C10352

US Classification:

424177

Abstract:

A morphine-like amidated opioid octapeptide metorphamide having the struce Try-Gly-Gly-Phe-Met-Arg-Arg-Val-NH. sub. 2 has been isolated from bovine caudate nucleus extracts and synthesized by solid phase peptide synthesis methods. Metorphamide is thus far the only natural opioid peptide having a high. mu. -binding activity.

Use Of Arg-Phe-Amide Derivatives

US Patent:

4587233, May 6, 1986

Filed:

Nov 7, 1983

Appl. No.:

6/549961

Inventors:

Jack D. Barchas - Stanford CA
Eckard Weber - Palo Alto CA
Christopher J. Evans - Palo Alto CA
E. T. Wei - El Cerrito CA
J. K. Chang - San Carlos CA
Ingbert Fuchs - De Soto TX
Gabriele Mues - De Soto TX

Assignee:

Board of Trustees of the Leland Stanford Junior University - Stanford CA

International Classification:

A61K 3700

US Classification:

514 15

Abstract:

A method is provided for elevating blood pressure in mammals comprising the step of administering a polypeptide containing the C-terminal residue L-Arg-L-Phe or C-terminal esters or amides thereof.