Inventors:
Alan D. T. Barrett - Galveston TX
David Niesel - League City TX
Christopher Robb - Galveston TX
Haolin Ni - Galveston TX
Assignee:
The Board of Trustees of the University of Texas System - Austin TX
International Classification:
C12P 2104, A61K 39003, C12N 1500, C12N 112
Abstract:
The present invention provides a Mycobacterium-E. coli shuttle vector containing sequences coding for a tribrid fusion containing the M. leprae 18kDa antigen sequence, a phoA protein antigen sequence and a non-mycobacterial, non-E. coli heterologous protein antigen sequence. Also provided is a method of producing protective immunity in an animal or human host in need of such treatment, comprising the step of administering to said animal or human host an effective dose of recombinant mycobacteria carrying the vector of the present invention.