Inventors:
James R. Shanklin - Richmond VA
Christopher P. Johnson - Richmond VA
Assignee:
A. H. Robins Company, Incorporated - Richmond VA
International Classification:
A61K 31445, A61K 3140, A61K 3155, C07D21122
Abstract:
Novel heterocyclicmethanols are disclosed having the formula: ##STR1## wherein Z is pyrrolidinyl, piperidinyl, homopiperidinyl or pyridinyl; R. sup. 1 is hydrogen, loweralkyl or carbethoxymethyl;
R. sup. 2 is hydrogen, loweralkyl, cycloalkyl, phenyl or phenyl-loweralkyl;
R. sup. 3 is 1 or 2-naphthalenyl, 2,3-dihydroinden-4 or 5-yl, phenyl or phenyl substituted by loweralkyl, loweralkoxy, halogen, trifluoromethyl, phenyl, methylenedioxy, nitro, amino, loweralkylamino, diloweralkylamino, loweracylamino;
the 1-position of 2-pyrrolidinyl, 2-piperidinyl or 2-homopiperidinyl may be substituted by an R. sup. 4 loweralkyl group, or R. sup. 1 may form methylene or --CH. sub. 2 -C(O)-bridges with R. sup. 4 ;
the pharmaceutically acceptable salts and diastereomers thereof, which compounds have antiarrhythmic and/or hypotensive activity in animals.