DR. CHRISTOPHER JOHN DESTACHE, PHARM. D.
Pharmacy at 30 St, Omaha, NE
License number
Nebraska 9813
Category
Pharmacy
Type
Pharmacist
License number
Nebraska 9813
Category
Pharmacy
Type
Pharmacotherapy
Address
Address
601 N 30Th St SUITE 5800, Omaha, NE 68131
Phone
(402) 280-4269
(402) 280-4744
(402) 280-3320 (Fax)
(402) 280-4744
(402) 280-3320 (Fax)
Personal information
See more information about CHRISTOPHER JOHN DESTACHE at radaris.comName
Address
Phone
5211 S 166Th Avenue Cir, Omaha, NE 68135
5211 S 166Th Avenue Cir, Omaha, NE 68135
Professional information
Nanoparticles And Methods Of Use
US Patent:
2011023, Sep 29, 2011
Filed:
Dec 11, 2009
Appl. No.:
13/132442
Inventors:
Christopher J. Destache - Omaha NE, US
Assignee:
Creighton University - Omaha NE
International Classification:
A61K 9/14, C12N 5/071, A61K 31/536, A61K 31/675, A61K 31/513, A61K 31/7072, A61K 31/708, A61K 31/7068, A61K 31/52, A61P 31/12, A61P 31/18, A61P 31/14, B82Y 5/00
US Classification:
424400, 435375, 5142305, 514 80, 514269, 514 50, 514 45, 514 49, 5142634, 514274, 977773, 977906
Abstract:
Provided herein are nanoparticles and methods for using nanoparticles. The nanoparticles include at least three antiretroviral agents. When introduced to cells the nanoparticles cause an increase in the intracellular concentration of the antiretroviral agents to a level that is at least the IC50 against HIV-I or HIV-2. This concentration may be maintained for at least 21 days after the cells are contacted with the nanoparticle. When administered to a subject the nanoparticles cause the concentration of the antiretroviral agents to increase to at least 100 ng/ml in the serum of the subject, at least 0.5 μg/gram tissue in an organ of the subject, or a combination thereof. Such a concentration may be maintained for at least 21 days after the administration.