Inventors:
Alan Bradley Fulp - Williow Spring NC, US
Matthew Scott Johnson - Durham NC, US
Christopher John Markworth - Durham NC, US
Brian Edward Marron - Durham NC, US
Darrick Conway Seconi - Cary NC, US
Christopher William West - Cary NC, US
Xiaodong Wang - Chapel Hill NC, US
Shulan Zhou - Chapel Hill NC, US
International Classification:
C07D 409/12, A61K 31/44
US Classification:
514275, 514342, 514370, 544322, 5462707, 548197
Abstract:
Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through voltage-gated sodium channels. More particularly, the invention provides substituted sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the indicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pain by the inhibition of ion flux through a voltage-gated sodium channel.