CHRISTOPHER F YEE
Engineering in Needham, MA
License number
Massachusetts 24375
Issued Date
May 15, 2014
Type
Engineer in Training
Address
Address
Needham, MA 02492
Professional information
Inha Inhibitors And Methods Of Use Thereof
US Patent:
6372752, Apr 16, 2002
Filed:
Feb 7, 2000
Appl. No.:
09/499183
Inventors:
Mark M. Staveski - Taunton MA
Scott F. Sneddon - Salem MA
Christopher Yee - Needham MA
Andrew Janjigian - Cambridge MA
Scott F. Sneddon - Salem MA
Christopher Yee - Needham MA
Andrew Janjigian - Cambridge MA
Assignee:
Genzyme Corporation - Cambridge MA
International Classification:
A61K 31505
US Classification:
514273, 514249, 514256, 544331, 544333, 544353
Abstract:
The invention relates to compounds which inhibit the Mycobacterial enoyl-ACP reductase required for cell wall biosynthesis. The invention also relates to pharmaceutical compositions comprising these compounds and to methods of use of these compounds for treating a bacterial infection in a patient.
Novel Small Molecules With Selective Cytotoxicity Against Human Microvascular Endothelial Cell Proliferation
US Patent:
2007025, Nov 1, 2007
Filed:
Jan 9, 2007
Appl. No.:
11/651406
Inventors:
John Kane - Maynard MA, US
Bradford Hirth - Littleton MA, US
Christopher Yee - Needham MA, US
Mark Staveski - Taunton MA, US
Hans-Peter Biemann - Cambridge MA, US
Marko Pregel - Arlington MA, US
Bradford Hirth - Littleton MA, US
Christopher Yee - Needham MA, US
Mark Staveski - Taunton MA, US
Hans-Peter Biemann - Cambridge MA, US
Marko Pregel - Arlington MA, US
International Classification:
A61K 31/4709, A61K 31/497, A61P 9/00, C07D 215/38, C07D 243/08, C07D 401/14, C07D 413/14
US Classification:
514253060, 514314000, 540575000, 544128000, 544238000, 544353000, 544363000, 546171000
Abstract:
Disclosed herein are angiogenesis inhibitors represented by formula (I) or formula (II):
The variables for formulas (I) and (II) are defined herein.
Enzymatic Resolution Of .Alpha.-Tertiary Carboxylic Acid Esters
US Patent:
5492830, Feb 20, 1996
Filed:
Jun 25, 1993
Appl. No.:
8/083943
Inventors:
Christopher Yee - Needham MA
Todd Blythe - Malden MA
Spencer Shames - Concord MA
Elizabeth Rogers - Cambridge MA
Todd Blythe - Malden MA
Spencer Shames - Concord MA
Elizabeth Rogers - Cambridge MA
Assignee:
Genzyme Corporation - Cambridge MA
International Classification:
C12N 948, C12P 762, C12P 4100
US Classification:
435280
Abstract:
A method for the resolution of. alpha. -tertiary carboxylic acid esters by partial hydrolysis is disclosed. The partial hydrolysis is carried out by contacting the esters with an aqueous solution in the presence of a serine carboxypeptidase, and the hydrolysis product is separated from unreacted starting material to obtain the hydrolysis product or the unreacted starting material in enantiomerically enriched form. A novel ester hydrolase which is particularly useful in this method, and a nucleotide sequence encoding this enzyme, are also described.
Resolution Of .Alpha.-Tertiary Carboxylic Acid Esters Using Lipase From Candida Lipolytica
US Patent:
5202260, Apr 13, 1993
Filed:
May 8, 1991
Appl. No.:
7/697152
Inventors:
Christopher Yee - Needham MA
Todd A. Blythe - Boston MA
Alan E. Walts - Reading MA
Todd A. Blythe - Boston MA
Alan E. Walts - Reading MA
Assignee:
Genzyme Corporation - Cambridge MA
International Classification:
C12P 740
US Classification:
435280
Abstract:
A method for the resolution of. alpha. -tertiary carboxylic acid esters by partial hydrolysis is disclosed. The partial hydrolysis is carried out by contacting the esters with an aqueous solution in the presence of a lipase derived from Candida lipolytica, and the hydrolysis product is separated from unreacted starting material to obtain the hydrolysis product or the unreacted starting material in enantiomerically enriched form.
Inhibitors Of Sphingosine Kinase 1
US Patent:
2011027, Nov 10, 2011
Filed:
Sep 17, 2009
Appl. No.:
13/119386
Inventors:
Yibin Xiang - Acton MA, US
Bradford Hirth - Littleton MA, US
John L. Kane - Maynard MA, US
Junkai Liao - Tewksbury MA, US
Kevin Noson - San Francisco CA, US
Christopher Yee - Needham MA, US
Bradford Hirth - Littleton MA, US
John L. Kane - Maynard MA, US
Junkai Liao - Tewksbury MA, US
Kevin Noson - San Francisco CA, US
Christopher Yee - Needham MA, US
International Classification:
A61K 31/454, A61K 31/4439, A61K 31/4245, A61K 31/427, A61K 31/4192, A61K 31/4155, A61K 31/404, A61K 31/4025, C07D 413/12, C07D 211/22, C07D 401/12, C07D 417/12, A61K 31/4196, C07D 403/12, C07D 405/12, A61P 35/00, A61P 3/10, A61P 31/18, A61P 31/12, A61K 31/45
US Classification:
514326, 514327, 514343, 514364, 514365, 514383, 514406, 514414, 514422, 546209, 546221, 5462784, 548131, 548204, 548255, 5482662, 5483641, 548467, 548525
Abstract:
The invention relates to compounds of Formula (I). Compounds of the present invention are inhibitors of sphingosine kinase 3, and are useful in the treatment of various disorders and conditions, such as inflammatory disorders.