DR. CHRISTOPHER F SMITH, MD
Osteopathic Medicine at Dtc Pkwy, Englewood, CO
License number
Colorado 21848
Category
Osteopathic Medicine
Type
Internal Medicine
Address
Address
5200 Dtc Pkwy SUITE 400, Englewood, CO 80111
Phone
(303) 745-0000
(303) 773-3101 (Fax)
(303) 773-3101 (Fax)
Professional information
Team Leader At Gevo
Position:
Team Leader at Gevo
Location:
Greater Denver Area
Industry:
Research
Work:
Gevo
- Englewood, CO since Apr 2012
-
Team Leader
Gevo
Mar 2008 - Mar 2012
-
Research Scientist/Molecular Biologist
University of Utah
- Salt Lake City, UT Sep 2007 - Dec 2007
-
Postdoctoral Researcher
Colorado Department of Public Health & Environment
Apr 2001 - May 2002
-
Laboratory Technician
University of Maryland Varsity Football Team
May 2000 - Jan 2001
-
Graduate Assistant Football Coach
Education:
University of Wyoming 2002 - 2007
PhD, Molecular Biology University of Michigan Law School 1999 - 1999
Colorado College 1994 - 1998
BA, Chemistry
PhD, Molecular Biology University of Michigan Law School 1999 - 1999
Colorado College 1994 - 1998
BA, Chemistry
Skills:
Biochemistry, Molecular Biology, Biotechnology, Science, PCR, Microbiology, qRT-PCR, Cloning, Molecular Cloning, Yeast Strain Engineering, Enzyme Assays, qPCR, Biofuels, Laboratory, Western Blotting, DNA, Lifesciences, Technology Transfer, Cell Biology
Christopher Smith - Englewood, CO
Work:
Sears via Mile High Staffing - Brighton, CO
Material Handler Skin & Bonez Piecing & Body Modifications - Lakewood, CO
Body Artist 3-D Eyecandy - Golden, CO
Sculptor/General laborer
Material Handler Skin & Bonez Piecing & Body Modifications - Lakewood, CO
Body Artist 3-D Eyecandy - Golden, CO
Sculptor/General laborer
Education:
Richlands High School - Richlands, NC
Diploma Westwood College - Denver, CO
Graphic Design
Diploma Westwood College - Denver, CO
Graphic Design
Yeast Organism Producing Isobutanol At A High Yield
US Patent:
8017375, Sep 13, 2011
Filed:
Dec 23, 2008
Appl. No.:
12/343375
Inventors:
Reid M. Renny Feldman - Highlands Ranch CO, US
Uvini Gunawardena - Irvine CA, US
Jun Urano - Aurora CO, US
Peter Meinhold - Denver CO, US
Aristos A. Aristidou - Highlands Ranch CO, US
Catherine Asleson Dundon - Englewood CO, US
Christopher Smith - Englewood CO, US
Uvini Gunawardena - Irvine CA, US
Jun Urano - Aurora CO, US
Peter Meinhold - Denver CO, US
Aristos A. Aristidou - Highlands Ranch CO, US
Catherine Asleson Dundon - Englewood CO, US
Christopher Smith - Englewood CO, US
Assignee:
Gevo, Inc. - Englewood CO
International Classification:
C12P 7/04, C12P 7/16, C12N 1/15, C12N 1/16, C12N 15/00, C12N 9/88
US Classification:
4352542, 43525421, 435157, 435160, 4353201, 435232
Abstract:
There is disclosed a method of producing isobutanol. In an embodiment, the method includes providing a microorganism transformed with an isobutanol producing pathway containing at least one exogenous gene. The microorganism is selected to produce isobutanol from a carbon source at a yield of at least 10 percent theoretical. The method includes cultivating the microorganism in a culture medium containing a feedstock providing the carbon source, until isobutanol is produced. The method includes recovering the isobutanol. In one embodiment, the microorganism is a yeast with a Crabtree-negative phenotype. In another embodiment, the microorganism is a yeast microorganism with a Crabtree-positive phenotype. There is disclosed a microorganism for producing isobutanol. In an embodiment, the microorganism includes an isobutanol producing pathway containing at least one exogenous gene, and is selected to produce a recoverable quantity of isobutanol from a carbon source at a yield of at least 10 percent theoretical.
Methods Of Increasing Dihydroxy Acid Dehydratase Activity To Improve Production Of Fuels, Chemicals, And Amino Acids
US Patent:
2012028, Nov 15, 2012
Filed:
Jun 20, 2012
Appl. No.:
13/528106
Inventors:
Jun Urano - Irvine CA, US
Catherine Asleson Dundon - Englewood CO, US
Peter Meinhold - Denver CO, US
Reid M. Renny Feldman - San Francisco CA, US
Aristos Aristidou - Englewood CO, US
Andrew Hawkins - Parker CO, US
Thomas Buelter - Denver CO, US
Matthew Peters - Highlands Ranch CO, US
Doug Lies - Parker CO, US
Christopher Smith - Englewood CO, US
Lynne H. Albert - Englewood CO, US
Catherine Asleson Dundon - Englewood CO, US
Peter Meinhold - Denver CO, US
Reid M. Renny Feldman - San Francisco CA, US
Aristos Aristidou - Englewood CO, US
Andrew Hawkins - Parker CO, US
Thomas Buelter - Denver CO, US
Matthew Peters - Highlands Ranch CO, US
Doug Lies - Parker CO, US
Christopher Smith - Englewood CO, US
Lynne H. Albert - Englewood CO, US
Assignee:
Gevo, Inc. - Englewood CO
International Classification:
C12P 7/16, C12N 1/19
US Classification:
435160, 4352542, 43525421, 43525423, 43525422
Abstract:
The present invention is directed to recombinant microorganisms comprising one or more dihydroxyacid dehydratase (DHAD)-requiring biosynthetic pathways and methods of using said recombinant microorganisms to produce beneficial metabolites derived from said DHAD-requiring biosynthetic pathways. In various aspects of the invention, the recombinant microorganisms may be engineered to overexpress one or more polynucleotides encoding one or more Aft proteins or homologs thereof. In some embodiments, the recombinant microorganisms may comprise a cytosolically localized DHAD enzyme. In additional embodiments, the recombinant microorganisms may comprise a mitochondrially localized DHAD enzyme. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the , Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.
Yeast Organism Producing Isobutanol At A High Yield
US Patent:
2011031, Dec 29, 2011
Filed:
Sep 9, 2011
Appl. No.:
13/229438
Inventors:
Reid M. Renny Feldman - San Francisco CA, US
Uvini Gunawardena - Irvine CA, US
Jun Urano - Aurora CO, US
Peter Meinhold - Denver CO, US
Aristos A. Aristidou - Highlands Ranch CO, US
Catherine Asleson Dundon - Englewood CO, US
Christopher Smith - Englewood CO, US
Uvini Gunawardena - Irvine CA, US
Jun Urano - Aurora CO, US
Peter Meinhold - Denver CO, US
Aristos A. Aristidou - Highlands Ranch CO, US
Catherine Asleson Dundon - Englewood CO, US
Christopher Smith - Englewood CO, US
Assignee:
GEVO, INC. - Englewood CO
International Classification:
C12P 7/16
US Classification:
435160
Abstract:
There is disclosed a method of producing isobutanol. In an embodiment, the method includes providing a microorganism transformed with an isobutanol producing pathway containing at least one exogenous gene. The microorganism is selected to produce isobutanol from a carbon source at a yield of at least 10 percent theoretical. The method includes cultivating the microorganism in a culture medium containing a feedstock providing the carbon source, until isobutanol is produced. The method includes recovering the isobutanol. In one embodiment, the microorganism is a yeast with a Crabtree-negative phenotype. In another embodiment, the microorganism is a yeast microorganism with a Crabtree-positive phenotype. There is disclosed a microorganism for producing isobutanol. In an embodiment, the microorganism includes an isobutanol producing pathway containing at least one exogenous gene, and is selected to produce a recoverable quantity of isobutanol from a carbon source at a yield of at least 10 percent theoretical.
Isobutanol Production Using Yeasts With Modified Transporter Expression
US Patent:
2013030, Nov 14, 2013
Filed:
May 31, 2011
Appl. No.:
13/701247
Inventors:
Catherine Asleson Dundon - Englewood CO, US
Christopher Smith - Englewood CO, US
Piruz Nahreini - Broomfield CO, US
John Thevelein - Blanden, BE
Sofie Saerens - Copenhagen NV, DK
Christopher Smith - Englewood CO, US
Piruz Nahreini - Broomfield CO, US
John Thevelein - Blanden, BE
Sofie Saerens - Copenhagen NV, DK
International Classification:
C12N 15/81, C12P 7/16
US Classification:
435160, 4352542, 43525421, 43525423, 43525422
Abstract:
The present invention relates to recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise one or more modifications resulting in the reduction in the expression and/or activity of an endogenous transporter protein. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the Glade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.
Yeast Organism Producing Isobutanol At A High Yield
US Patent:
2013025, Sep 26, 2013
Filed:
May 31, 2013
Appl. No.:
13/907394
Inventors:
Uvini Gunawardena - Irvine CA, US
Jun Urano - Aurora CO, US
Peter Meinhold - Denver CO, US
Aristos Aristidou - Highlands Ranch CO, US
Catherine Asleson Dundon - Englewood CO, US
Christopher Smith - Englewood CO, US
Jun Urano - Aurora CO, US
Peter Meinhold - Denver CO, US
Aristos Aristidou - Highlands Ranch CO, US
Catherine Asleson Dundon - Englewood CO, US
Christopher Smith - Englewood CO, US
Assignee:
GEVO, INC. - Englewood CO
International Classification:
C12N 15/81, C12P 7/16
US Classification:
435160, 4352542, 43525421, 43525422, 43525423
Abstract:
The present invention provides recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise a modification resulting in the reduction of pyruvate decarboxylase and/or glycerol-3-phosphate dehydrogenase activity. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.
Yeast Organism Producing Isobutanol At A High Yield
US Patent:
8455239, Jun 4, 2013
Filed:
Jun 22, 2010
Appl. No.:
12/820505
Inventors:
Reid M. Renny Feldman - San Marino CA, US
Uvini Gunawardena - Irvine CA, US
Jun Urano - Aurora CO, US
Peter Meinhold - Denver CO, US
Aristos Aristidou - Highlands Ranch CO, US
Catherine Asleson Dundon - Englewood CO, US
Christopher Smith - Englewood CO, US
Uvini Gunawardena - Irvine CA, US
Jun Urano - Aurora CO, US
Peter Meinhold - Denver CO, US
Aristos Aristidou - Highlands Ranch CO, US
Catherine Asleson Dundon - Englewood CO, US
Christopher Smith - Englewood CO, US
Assignee:
Gevo, Inc. - Englewood CO
International Classification:
C12P 7/04, C12P 7/16, C12N 1/15, C12N 1/16, C12N 15/00, C12N 9/88
US Classification:
4352542, 43525421, 435157, 435160, 4353201, 435232
Abstract:
The present invention provides recombinant mircoorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise a modification resulting in the reduction of pyruvate decarboxylase and/or glycerol-3-phosphate dehydrogenase activity. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.
Yeast Organism Producing Isobutanol At A High Yield
US Patent:
2012002, Feb 2, 2012
Filed:
Oct 6, 2011
Appl. No.:
13/267771
Inventors:
Reid M. Renny Feldman - San Francisco CA, US
Uvini Gunawardena - Irvine CA, US
Jun Urano - Aurora CO, US
Peter Meinhold - Denver CO, US
Aristos Aristidou - Highlands Ranch CO, US
Catherine Asleson Dundon - Englewood CO, US
Christopher Smith - Englewood CO, US
Uvini Gunawardena - Irvine CA, US
Jun Urano - Aurora CO, US
Peter Meinhold - Denver CO, US
Aristos Aristidou - Highlands Ranch CO, US
Catherine Asleson Dundon - Englewood CO, US
Christopher Smith - Englewood CO, US
Assignee:
GEVO, INC. - Englewood CO
International Classification:
C12P 7/16, C12N 1/19
US Classification:
435160, 4352542, 43525421
Abstract:
The present invention provides recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms may comprise a modification resulting in the reduction of pyruvate decarboxylase and/or glycerol-3-phosphate dehydrogenase activity. In various embodiments described herein, the recombinant microorganisms may be microorganisms of the clade, Crabtree-negative yeast microorganisms, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.
Engineered Microorganisms For The Production Of One Or More Target Compounds
US Patent:
2012004, Feb 23, 2012
Filed:
Dec 23, 2009
Appl. No.:
13/141648
Inventors:
Thomas Buelter - Denver CO, US
Peter Meinhold - Denver CO, US
Christopher Smith - Englewood CO, US
Aristos Aristidou - Highlands Ranch CO, US
Catherine Asleson Dundon - Englewood CO, US
Jun Urano - Aurora CO, US
Peter Meinhold - Denver CO, US
Christopher Smith - Englewood CO, US
Aristos Aristidou - Highlands Ranch CO, US
Catherine Asleson Dundon - Englewood CO, US
Jun Urano - Aurora CO, US
Assignee:
GEVO, INC. - Englewood CO
International Classification:
C12P 7/16, C12N 1/19
US Classification:
435160, 4352542
Abstract:
The present invention provides recombinant microorganisms comprising an isobutanol producing metabolic pathway and methods of using said recombinant microorganisms to produce isobutanol. In various aspects of the invention, the recombinant microorganisms comprise isobutanol producing metabolic pathway with one or more isobutanol pathway enzymes localized in the mitochondria. In various embodiments described herein, the recombinant microorganisms may be Crabtree-negative yeast microorganisms, microorganisms of the clade, Crabtree-positive yeast microorganisms, post-WGD (whole genome duplication) yeast microorganisms, pre-WGD (whole genome duplication) yeast microorganisms, and non-fermenting yeast microorganisms.