CHRISTOPHER CORCORAN
Accountancy in Arlington, MA
License number
Massachusetts 3419
Issued Date
Jun 30, 1979
Expiration Date
Jun 30, 1981
Type
Certified Public Accountant
Address
Address
Arlington, MA 02474
Professional information
Proteases And Uses Thereof
US Patent:
2005026, Nov 24, 2005
Filed:
Apr 15, 2005
Appl. No.:
11/106623
Inventors:
Edward LaVallie - Harvard MA, US
Christopher Corcoran - Arlington MA, US
Michael Agostino - Andover MA, US
Bethany Freeman - Belmont MA, US
Maya Arai - Brookline MA, US
Carl Flannery - Acton MA, US
Macy Jin - Reading MA, US
Christopher Corcoran - Arlington MA, US
Michael Agostino - Andover MA, US
Bethany Freeman - Belmont MA, US
Maya Arai - Brookline MA, US
Carl Flannery - Acton MA, US
Macy Jin - Reading MA, US
Assignee:
WYETH - Cambridge MA
International Classification:
C12N009/64
US Classification:
435226000
Abstract:
The present invention features methods of using ADAMTS-8 proteins or their functional derivatives to cleave aggrecan or other proteoglycan molecules. The present invention also features methods for identifying ADAMTS-8 modulators that are capable of inhibiting or enhancing ADAMTS-8 proteolytic activities. In addition, the present invention features pharmaceutical compositions comprising ADAMTS-8 proteins or their derivatives or modulators. These pharmaceutical compositions can be used to treat diseases that are characterized by deficiencies or abnormalities in proteoglycan cleavage or metabolism.
Truncated Adamts Molecules
US Patent:
2005027, Dec 15, 2005
Filed:
Apr 18, 2005
Appl. No.:
11/109157
Inventors:
Edward LaVallie - Harvard MA, US
Christopher Corcoran - Arlington MA, US
Natalie Twine - Goffstown NH, US
Michael Agostino - Andover MA, US
Christopher Corcoran - Arlington MA, US
Natalie Twine - Goffstown NH, US
Michael Agostino - Andover MA, US
Assignee:
WYETH - Madison NJ
International Classification:
C12P021/06, C12N009/64, C07H021/04
US Classification:
435069100, 435226000, 435320100, 435325000, 536023200
Abstract:
The invention provides truncated biologically active ADAMTS polypeptides, particularly those with hyalectenase activity, and more particularly those with aggrecanase activity, that exhibit greater stability and homogeneity and higher expression yields than their full-length counterparts. The invention also provides nucleic acid molecules encoding such truncated biologically active ADAMTS polypeptides and methods for producing the truncated biologically active ADAMTS polypeptides. In addition, the invention provides methods for identifying compounds capable of modulating biologically active ADAMTS polypeptides, particularly those compounds that inhibit aggrecanase activity.
Modified Adamts4 Molecules And Method Of Use Thereof
US Patent:
7118902, Oct 10, 2006
Filed:
Jul 29, 2003
Appl. No.:
10/628432
Inventors:
Christopher John Corcoran - Arlington MA, US
Carl R. Flannery - Acton MA, US
Weilan Zeng - Waltham MA, US
Lisa A. Racie - Acton MA, US
Thomas McDonagh - Acton MA, US
Bethany A. Freeman - Arlington MA, US
Katy E. Georgiadis - Belmont MA, US
Edward R. LaVallie - Harvard MA, US
Carl R. Flannery - Acton MA, US
Weilan Zeng - Waltham MA, US
Lisa A. Racie - Acton MA, US
Thomas McDonagh - Acton MA, US
Bethany A. Freeman - Arlington MA, US
Katy E. Georgiadis - Belmont MA, US
Edward R. LaVallie - Harvard MA, US
Assignee:
Wyeth - Madison NJ
International Classification:
C12N 15/57, C12N 9/64, C12N 15/01, C12N 15/79
US Classification:
435226, 435 691, 4352523, 4353201, 435440
Abstract:
The present invention relates to modified ADAMTS4 proteins having improved stability comparing to the corresponding native, unmodified proteins. The modified ADAMTS4 proteins can be expressed and isolated in large quantities, thus allowing further characterization of the proteins, such as crystallographic and enzyme kinetic studies. The purified, stable proteins would also facilitate the production of anti-ADAMTS antibodies and the development of inhibitors to ADAMTS enzymes.
Recombinant Lubricin Molecules And Uses Thereof
US Patent:
7893029, Feb 22, 2011
Filed:
Nov 19, 2009
Appl. No.:
12/622141
Inventors:
Carl Ralph Flannery - Acton MA, US
Christopher John Corcoran - Arlington MA, US
Bethany Annis Freeman - Arlington MA, US
Christopher John Corcoran - Arlington MA, US
Bethany Annis Freeman - Arlington MA, US
Assignee:
Wyeth LLC - Madison NJ
International Classification:
A61K 38/39, C07K 14/47, C12P 21/02
US Classification:
514 12, 530350, 435 691
Abstract:
Recombinant lubricin molecules and uses thereof. Novel recombinant lubricin molecules and their uses as lubricants, anti-adhesive agents and/or intra-articular supplements for, e. g. , synovial joints, meniscus, tendon, peritoneum, pericardium and pleura, are provided.
Modified Adamts4 Molecules And Method Of Use Thereof
US Patent:
2006022, Oct 12, 2006
Filed:
Jun 12, 2006
Appl. No.:
11/451006
Inventors:
Christopher Corcoran - Arlington MA, US
Carl Flannery - Acton MA, US
Weilan Zeng - Waltham MA, US
Lisa Racie - Acton MA, US
Thomas McDonagh - Acton MA, US
Bethany Freeman - Arlington MA, US
Katy Georgiadis - Belmont MA, US
Edward LaVallie - Harvard MA, US
Carl Flannery - Acton MA, US
Weilan Zeng - Waltham MA, US
Lisa Racie - Acton MA, US
Thomas McDonagh - Acton MA, US
Bethany Freeman - Arlington MA, US
Katy Georgiadis - Belmont MA, US
Edward LaVallie - Harvard MA, US
Assignee:
Wyeth - Madison NJ
International Classification:
A61K 39/395, G01N 33/53, C07H 21/04, C12P 21/06, C07K 14/705
US Classification:
424143100, 435007100, 435069100, 435320100, 435325000, 530350000, 536023500
Abstract:
The present invention relates to modified ADAMTS4 proteins having improved stability comparing to the corresponding native, unmodified proteins. The modified ADAMTS4 proteins can be expressed and isolated in large quantities, thus allowing further characterization of the proteins, such as crystallographic and enzyme kinetic studies. The purified, stable proteins would also facilitate the production of anti-ADAMTS antibodies and the development of inhibitors to ADAMTS enzymes.
Recombinant Lubricin Molecules And Uses Thereof
US Patent:
7897571, Mar 1, 2011
Filed:
Nov 23, 2009
Appl. No.:
12/624112
Inventors:
Carl Ralph Flannery - Acton MA, US
Christopher John Corcoran - Arlington MA, US
Bethany Annis Freeman - Arlington MA, US
Christopher John Corcoran - Arlington MA, US
Bethany Annis Freeman - Arlington MA, US
Assignee:
Wyeth LLC - Madison NJ
International Classification:
A61K 38/39, C07K 14/47, C12P 21/02
US Classification:
514 12, 530350, 435 691
Abstract:
Recombinant lubricin molecules and uses thereof. Novel recombinant lubricin molecules and their uses as lubricants, anti-adhesive agents and/or intra-articular supplements for, e. g. , synovial joints, meniscus, tendon, peritoneum, pericardium and pleura, are provided.
Truncated Aggrecanase Molecules
US Patent:
7150983, Dec 19, 2006
Filed:
Feb 5, 2003
Appl. No.:
10/358283
Inventors:
Katy E. Georgiadis - Belmont MA, US
Tara K. Crawford - Cambridge MA, US
Kathleen N. Tomkinson - Cambridge MA, US
Christopher J. Corcoran - Arlington MA, US
Bethany A. Freeman - Arlington MA, US
Edward R. Lavallie - Harvard MA, US
Tara K. Crawford - Cambridge MA, US
Kathleen N. Tomkinson - Cambridge MA, US
Christopher J. Corcoran - Arlington MA, US
Bethany A. Freeman - Arlington MA, US
Edward R. Lavallie - Harvard MA, US
Assignee:
Wyeth - Madison NJ
International Classification:
C12N 9/64, C12P 21/04, C07H 21/04
US Classification:
435226, 435 697, 536 232
Abstract:
Truncated aggrecanase proteins and nucleotides sequences encoding them as well as processes for producing them are disclosed. Additionally, aggrecanases with amino acid mutations that lead to increased stability and expression levels in comparison with wild-type or native aggrecanases are also disclosed. Aggrecanases of the invention are especially useful for development of compositions for treatment of diseases such as osteoarthritis. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
Truncated Aggrecanase Molecules
US Patent:
7223858, May 29, 2007
Filed:
Jul 18, 2006
Appl. No.:
11/488340
Inventors:
Katy E. Georgiadis - Belmont MA, US
Tara K. Crawford - Cambridge MA, US
Kathleen N. Tomkinson - Cambridge MA, US
Christopher J. Corcoran - Arlington MA, US
Bethany A. Freeman - Arlington MA, US
Edward R. LaVallie - Harvard MA, US
Tara K. Crawford - Cambridge MA, US
Kathleen N. Tomkinson - Cambridge MA, US
Christopher J. Corcoran - Arlington MA, US
Bethany A. Freeman - Arlington MA, US
Edward R. LaVallie - Harvard MA, US
Assignee:
Wyeth - Madison NJ
International Classification:
C07H 21/04, C12N 9/64
US Classification:
5362322, 536 234, 435226
Abstract:
Truncated aggrecanase proteins and nucleotides sequences encoding them as well as processes for producing them are disclosed. Additionally, aggrecanases with amino acid mutations that lead to increased stability and expression levels in comparison with wild-type or native aggrecanases are also disclosed. Aggrecanases of the invention are especially useful for development of compositions for treatment of diseases such as osteoarthritis. Methods for developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
Aggrecanase Molecules
US Patent:
7078217, Jul 18, 2006
Filed:
Jan 31, 2003
Appl. No.:
10/354983
Inventors:
Christopher J. Corcoran - Arlington MA, US
Michael J. Agostino - Andover MA, US
Edward R. LaVallie - Harvard MA, US
Carl R. Flannery - Acton MA, US
Michael J. Agostino - Andover MA, US
Edward R. LaVallie - Harvard MA, US
Carl R. Flannery - Acton MA, US
Assignee:
Wyeth - Madison NJ
International Classification:
C12N 9/64, C12N 1/21, C07H 21/04
US Classification:
435226, 4352523, 536 232
Abstract:
Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods of identifying and developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.
Aggrecanase Molecules
US Patent:
2007012, Jun 7, 2007
Filed:
May 22, 2006
Appl. No.:
11/438609
Inventors:
Christopher Corcoran - Arlington MA, US
Michael Agostino - Andover MA, US
Edward LaVallie - Harvard MA, US
Carl Flannery - Acton MA, US
Weilan Zeng - Waltham MA, US
Bethany Freeman - Arlington MA, US
Michael Agostino - Andover MA, US
Edward LaVallie - Harvard MA, US
Carl Flannery - Acton MA, US
Weilan Zeng - Waltham MA, US
Bethany Freeman - Arlington MA, US
Assignee:
Wyeth - Madison NJ
International Classification:
C12Q 1/68, G01N 33/53, G06F 19/00, C07H 21/04, C12N 9/64, C07K 16/40
US Classification:
435006000, 536023200, 435226000, 435320100, 435325000, 530388260, 435007100, 702019000
Abstract:
Novel aggrecanase proteins and the nucleotide sequences encoding them as well as processes for producing them are disclosed. Methods of identifying and developing inhibitors of the aggrecanase enzymes and antibodies to the enzymes for treatment of conditions characterized by the degradation of aggrecan are also disclosed.