Inventors:
Donald B. DeFranco - Pittsburgh PA
Clifton W. Callaway - Pittsburgh PA
Christopher Lipinski - Pittsburgh PA
Nianqing Xiao - Pittsburgh PA
Assignee:
University of Pittsburgh - Pittsburgh PA
International Classification:
A61K 3133
Abstract:
The present invention provides a method of inhibiting oxidative-stress induced cell death in a cell comprising contacting the cell with a composition comprising a benzoquinoid ansamycin. The present invention further provides a method of reducing neurological injury resulting from cardiac arrest or stroke comprising administering to a patient a composition comprising a benzoquinoid ansamycin.