Inventors:
Christine Pratilas - New York NY, US
Neal Rosen - New York NY, US
International Classification:
C12Q 1/68, C07H 21/00, C40B 40/08
Abstract:
The present invention provides identification of a thirty-five gene set that predicts the anticancer activity of inhibitors of the RAF/MEK/MAPK pathway, methods of qualifying cancer status in a subject, methods of identifying an anti-tumor response in a subject, methods of monitoring the efficacy of a therapeutic drug in a subject, and methods of identifying an agent useful in the treatment of a cancer based on expression of the thirty-five gene set.