Inventors:
Marcy E. MacDonald - Lexington MA
James F. Gusella - Framingham MA
Christine Ambrose - Charlestown MA
Assignee:
The General Hospital Corporation - Boston MA
International Classification:
C12N 1512, C12N 1563
Abstract:
This invention relates to a DNA segment which encodes at least one member of the family of mammalian G protein-coupled receptor kinases, which maps to the Huntington's disease region within the terminal cytogenic subband of the short arm of chromosome 4, 4p16. 3, between DNA marker D4S10 and the telomere region. Further, this invention provides the substantially purified expression product of a gene from the Huntington's disease region of the chromosome, as well as related diagnostic and therapeutic uses.